Cellosaurus cell line CWR-R1 (CVCL

Cellosaurus CWR-R1 (CVCL_4833)

[Text version]

Cell line name

CWR-R1

Accession

CVCL_4833

Resource Identification Initiative

To cite this cell line use: CWR-R1 (RRID:CVCL_4833)

Comments

Population: Caucasian.
Characteristics: Co-culture of polygonal closely aggregated epithelial cells surrounded by bipolar stromal fibroblasts.
Doubling time: 33.57 hours (JWGray panel).
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Prostate; UBERON=UBERON_0002367.

Sequence variations

Mutation; HGNC; 644; AR; Simple; p.His875Tyr (c.2623C>T); ClinVar=VCV000009834; Zygosity=Hemizygous (PubMed=11306464).
Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Unspecified (PubMed=14518029).
Mutation; HGNC; 11998; TP53; Simple; p.Gln331Arg (c.992A>G); ClinVar=VCV000421319; Zygosity=Unspecified (PubMed=14518029).

Disease

Prostate carcinoma (NCIt: C4863)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Parent: CVCL_3967 (CWR22)
Children:

CVCL_ZC60 (CWR-R1-AD1)	CVCL_RA55 (CWR-R1-EnzR)	CVCL_LI36 (CWR-R1ca)
CVCL_LI37 (CWR-R1fb)

Sex of cell

Male

Age at sampling

Adult

Category

Cancer cell line

STR profile

Source(s): PubMed=14518029

Markers:

Amelogenin	X,Y
D3S1358	12,13,14
D5S818	11,12
D7S820	9,10,12
D8S1179	13,14
D13S317	8,12
D18S51	13,14,15
D21S11	30
FGA	20,23
vWA	15,16,19

Publications

PubMed=11306464
Gregory C.W., Johnson R.T. Jr., Mohler J.L., French F.S., Wilson E.M.
Androgen receptor stabilization in recurrent prostate cancer is associated with hypersensitivity to low androgen.
Cancer Res. 61:2892-2898(2001)

PubMed=14518029; DOI=10.1002/pros.10290
van Bokhoven A., Varella-Garcia M., Korch C.T., Johannes W.U., Smith E.E., Miller H.L., Nordeen S.K., Miller G.J., Lucia M.S.
Molecular characterization of human prostate carcinoma cell lines.
Prostate 57:205-225(2003)

PubMed=14518030; DOI=10.1002/pros.10291
van Bokhoven A., Caires A., Di Maria M., Schulte A.P., Lucia M.S., Nordeen S.K., Miller G.J., Varella-Garcia M.
Spectral karyotype (SKY) analysis of human prostate carcinoma cell lines.
Prostate 57:226-244(2003)

CLPUB00698
van Bokhoven A.
Models for prostate cancer. Molecular characterization and critical appraisal of human prostate carcinoma cell lines.
Thesis PhD (2004); Katholieke Universiteit Nijmegen; Nijmegen; Netherlands

PubMed=23117885; DOI=10.1158/0008-5472.CAN-12-3630; PMCID=PMC3549016
Li Y.-M., Chan S.-C., Brand L.J., Hwang T.H., Silverstein K.A.T., Dehm S.M.
Androgen receptor splice variants mediate enzalutamide resistance in castration-resistant prostate cancer cell lines.
Cancer Res. 73:483-489(2013)

PubMed=27036029; DOI=10.18632/oncotarget.8456; PMCID=PMC5041979
Kregel S., Chen J.L., Tom W., Krishnan V., Kach J., Brechka H., Fessenden T.B., Isikbay M., Paner G.P., Szmulewitz R.Z., Vander Griend D.J.
Acquired resistance to the second-generation androgen receptor antagonist enzalutamide in castration-resistant prostate cancer.
Oncotarget 7:26259-26274(2016)

PubMed=27271795; DOI=10.1002/pros.23190
Shourideh M., DePriest A., Mohler J.L., Wilson E.M., Koochekpour S.
Characterization of fibroblast-free CWR-R1ca castration-recurrent prostate cancer cell line.
Prostate 76:1067-1077(2016)

Cross-references

Cell line collections (Providers)

Kerafast; ENC005 - Discontinued

Cell line databases/resources

cancercelllines; CVCL_4833

Encyclopedic resources

Wikidata; Q54817049

Experimental variables resources

EFO; EFO_0022645

Gene expression databases