Cellosaurus cell line CWR-R1-AD1 (CVCL

Cellosaurus CWR-R1-AD1 (CVCL_ZC60)

[Text version]

Cell line name

CWR-R1-AD1

Synonyms

R1-AD1

Accession

CVCL_ZC60

Resource Identification Initiative

To cite this cell line use: CWR-R1-AD1 (RRID:CVCL_ZC60)

Comments

Population: Caucasian.
Characteristics: Clone of CWR-R1 that harbors one intact AR gene copy, express full-length AR and exhibit growth stimulation in response to androgens and growth suppression in response to AR antagonists, including enzalutamide (PubMed=24101480).
Derived from site: In situ; Prostate; UBERON=UBERON_0002367.

Sequence variations

Mutation; HGNC; HGNC:644; AR; Simple; p.His875Tyr (c.2623C>T); ClinVar=VCV000009834; Zygosity=Hemizygous (from parent cell line).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Unspecified (from parent cell line).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln331Arg (c.992A>G); ClinVar=VCV000421319; Zygosity=Unspecified (from parent cell line).

Disease

Prostate carcinoma (NCIt: C4863)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Parent: CVCL_4833 (CWR-R1)
Children:

CVCL_ZC61 (CWR-R1-D567)

CVCL_ZC62 (CWR-R1-I567)

Sex of cell

Male

Age at sampling

Adult