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Cellosaurus Vero C1008 (CVCL_0574)

[Text version]
Cell line name Vero C1008
Synonyms VERO C1008; VeroC1008; VEROC1008; VERO C 1008; VERO C1008 (E6); Vero 76 clone E6; Vero 76 clone E-6; Vero E-6; Vero E6; VERO E6; Vero-E6; VeroE6
Accession CVCL_0574
Resource Identification Initiative To cite this cell line use: Vero C1008 (RRID:CVCL_0574)
Comments Group: Non-human primate cell line.
Group: Vaccine production cell line.
Virology: Susceptible to infection by many viruses. Supports the growth of slowly replicating viruses (ATCC=CRL-1586).
Virology: Susceptible to infection by SARS coronavirus (SARS-CoV). Produces a lytic infection (PubMed=15731278; PubMed=16494729).
Virology: Susceptible to infection by SARS coronavirus 2 (SARS-CoV-2) (COVID-19) (PubMed=32020029; PubMed=32511316; PubMed=33389257; PubMed=34339474).
Doubling time: 22 hours (ATCC=CRL-1586).
Derived from site: In situ; Kidney, epithelium; UBERON=UBERON_0004819.
Cell type: Epithelial cell of kidney; CL=CL_0002518.
Species of origin Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) (NCBI Taxonomy: 60711)
Hierarchy Parent: CVCL_0603 (Vero 76)
Children:
CVCL_D7CA (Abeomics Vero ACE2)CVCL_D7CB (Abeomics Vero GFP)CVCL_JX48 (sVero p66)
CVCL_E1F0 (Ubigene Vero E6 ATG7 KO)CVCL_E1F1 (Ubigene Vero E6 GSDME KO)CVCL_E1F2 (Ubigene Vero E6 PIK3C3 KO)
CVCL_E1F4 (Ubigene Vero E6 STAT1 KO)CVCL_E1F6 (Ubigene Vero E6 ZDHHC20 KO)CVCL_A7UJ (Vero E6-high ACE2)
CVCL_XD71 (Vero E6-S)CVCL_C7NK (Vero E6-TMPRSS2-T2A-ACE2)CVCL_YZ66 (Vero E6/NPC1-KO cl.19)
CVCL_C4RQ (VeroE6-Pgp-KO)CVCL_YQ49 (VeroE6/TMPRSS2)
Sex of cell Female
Age at sampling Adult
Category Spontaneously immortalized cell line
Web pages https://en.wikipedia.org/wiki/Vero_cell
https://en.vircell.com/products/vero-e6-cell-line/
Publications

CLPUB00328
Earley E.M., Johnson K.M.
The lineage of Vero, Vero 76 and its clone C1008 in the United States.
(In book chapter) Vero cells: origin, properties and biomedical applications; Simizu B., Terasima T. (eds.); pp.26-29; Department of Microbiology, School of Medicine, Chiba University; Chiba; Japan (1988)

PubMed=15731278; DOI=10.1128/JVI.79.6.3846-3850.2005; PMCID=PMC1075706
Mossel E.C., Huang C., Narayanan K., Makino S., Tesh R.B., Peters C.J.
Exogenous ACE2 expression allows refractory cell lines to support severe acute respiratory syndrome coronavirus replication.
J. Virol. 79:3846-3850(2005)

PubMed=16494729; DOI=10.3201/eid1201.050496; PMCID=PMC3291385
Kaye M., Druce J., Tran T., Kostecki R., Chibo D., Morris J., Catton M., Birch C.
SARS-associated coronavirus replication in cell lines.
Emerg. Infect. Dis. 12:128-133(2006)

PubMed=19016439; DOI=10.1002/9780471729259.mca04es11; PMCID=PMC2657228
Ammerman N.C., Beier-Sexton M., Azad A.F.
Growth and maintenance of Vero cell lines.
Curr. Protoc. Microbiol. 11:A.4E.1-A.4E.7(2008)

PubMed=32020029; DOI=10.1038/s41422-020-0282-0; PMCID=PMC7054408
Wang M.-L., Cao R.-Y., Zhang L.-K., Yang X.-L., Liu J., Xu M.-Y., Shi Z.-L., Hu Z.-H., Zhong W., Xiao G.-F.
Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro.
Cell Res. 30:269-271(2020)

PubMed=32511316; DOI=10.1101/2020.03.02.972935; PMCID=PMC7239045
Harcourt J.L., Tamin A., Lu X.-Y., Kamili S., Kumar-Sakthivel S., Murray J., Queen K., Tao Y., Paden C.R., Zhang J., Li Y., Uehara A., Wang H.-B., Goldsmith C., Bullock H.A., Wang L.-J., Whitaker B., Lynch B., Gautam R., Schindewolf C., Lokugamage K.G., Scharton D., Plante J.A., Mirchandani D., Widen S.G., Narayanan K., Makino S., Ksiazek T.G., Plante K.S., Weaver S.C., Lindstrom S., Tong S.-X., Menachery V.D., Thornburg N.J.
Isolation and characterization of SARS-CoV-2 from the first US COVID-19 patient.
bioRxiv 2020:972935-972935(2020)

PubMed=33389257; DOI=10.1007/s10096-020-04106-0; PMCID=PMC7778494
Wurtz N., Penant G., Jardot P., Duclos N., La Scola B.
Culture of SARS-CoV-2 in a panel of laboratory cell lines, permissivity, and differences in growth profile.
Eur. J. Clin. Microbiol. Infect. Dis. 40:477-484(2021)

PubMed=34339474; DOI=10.1371/journal.pone.0255622; PMCID=PMC8328321
Pommerenke C., Rand U., Uphoff C.C., Nagel S., Zaborski M., Hauer V., Kaufmann M., Meyer C., Denkmann S.A., Riese P., Eschke K., Kim Y., Safranko Z.M., Kurolt I.-C., Markotic A., Cicin-Sain L., Steenpass L.
Identification of cell lines CL-14, CL-40 and CAL-51 as suitable models for SARS-CoV-2 infection studies.
PLoS ONE 16:E0255622-E0255622(2021)

Cross-references
Cell line collections (Providers) ATCC; CRL-1586
BCRC; 60476
BCRJ; 0407
CCTCC; GDC0146
CLS; 305008
ECACC; 85020206
IZSLER; BS CL 87
Ubigene; YC-A003
Cell line databases/resources CLO; CLO_0009527
MCCL; MCC:0000479
CLDB; cl4656
CLDB; cl4657
CCRID; 1101MON-PUMC000388
CCRID; 1102MON-NIFDC00097
CCRID; 3101MONGNO17
CCRID; 4201MON-CCTCC00146
Anatomy/cell type resources BTO; BTO:0004755
CRISP screens repositories BioGRID_ORCS_Cell_line; 1349
Chemistry resources ChEMBL-Cells; CHEMBL4295411
ChEMBL-Targets; CHEMBL4303840
PubChem_Cell_line; CVCL_0574
Encyclopedic resources Wikidata; Q54993044
Gene expression databases GEO; GSM758827
GEO; GSM758828
GEO; GSM758829
GEO; GSM758830
GEO; GSM758831
GEO; GSM758832
GEO; GSM758833
GEO; GSM758834
GEO; GSM758835
GEO; GSM758836
GEO; GSM758837
GEO; GSM758838
GEO; GSM758839
GEO; GSM758840
GEO; GSM758841
GEO; GSM758842
GEO; GSM758843
GEO; GSM758844
Proteomic databases PRIDE; PXD018594
PRIDE; PXD018760
PRIDE; PXD019645
PRIDE; PXD023538
Entry history
Entry creation04-Apr-2012
Last entry update30-Jan-2024
Version number28