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Cellosaurus OV-2008 (CVCL_0473)

[Text version]
Cell line name OV-2008
Synonyms OV2008; Ov2008; OV 2008; 2008; A2008
Accession CVCL_0473
Secondary accession CVCL_4066
Resource Identification Initiative To cite this cell line use: OV-2008 (RRID:CVCL_0473)
Comments Problematic cell line: Contaminated. Shown to be a ME-180 derivative (PubMed=22710073). Originally thought to originate from a female patient with an ovarian serous carcinoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00466.
Population: Caucasian.
Transformant: NCBI_TaxID; 45240; Human papillomavirus type 68 (HPV68).
Omics: Transcriptome analysis by microarray.
Derived from site: Metastatic; Omentum; UBERON=UBERON_0003688.
Sequence variations
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (PubMed=25846456).
Disease Human papillomavirus-related cervical squamous cell carcinoma (NCIt: C27676)
Squamous cell carcinoma of the cervix uteri (ORDO: Orphanet_213767)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1401 (ME-180)
CVCL_0114 (2008/C13*5.25)CVCL_W373 (PX2)CVCL_W374 (PX24)
Sex of cell Female
Age at sampling 66Y
Category Cancer cell line
STR profile Source(s): PubMed=22710073


Run an STR similarity search on this cell line
Web pages https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/2/cell-lines-detail-62.html

PubMed=4118903; DOI=10.1016/0002-9378(72)90109-3
DiSaia P.J., Sinkovics J.G., Rutledge F.N., Smith J.P.
Cell-mediated immunity to human malignant cells. A brief review and further studies with two gynecologic tumors.
Am. J. Obstet. Gynecol. 114:979-989(1972)

PubMed=9234707; DOI=10.1128/mcb.17.8.4501
Bullions L.C., Notterman D.A., Chung L.S., Levine A.J.
Expression of wild-type alpha-catenin protein in cells with a mutant alpha-catenin gene restores both growth regulation and tumor suppressor activities.
Mol. Cell. Biol. 17:4501-4508(1997)

PubMed=11314036; DOI=10.1038/sj.onc.1204211
Forgacs E., Wren J.D., Kamibayashi C., Kondo M., Xu X.L., Markowitz S.D., Tomlinson G.E., Muller C.Y., Gazdar A.F., Garner H.R., Minna J.D.
Searching for microsatellite mutations in coding regions in lung, breast, ovarian and colorectal cancers.
Oncogene 20:1005-1009(2001)

PubMed=19926575; DOI=10.1309/AJCPTK87EMMIKPFS
DeRycke M.S., Andersen J.D., Harrington K.M., Pambuccian S.E., Kalloger S.E., Boylan K.L.M., Argenta P.A., Skubitz A.P.N.
S100A1 expression in ovarian and endometrial endometrioid carcinomas is a prognostic indicator of relapse-free survival.
Am. J. Clin. Pathol. 132:846-856(2009)

PubMed=22710073; DOI=10.1016/j.ygyno.2012.06.017
Korch C.T., Spillman M.A., Jackson T.A., Jacobsen B.M., Murphy S.K., Lessey B.A., Jordan V.C., Bradford A.P.
DNA profiling analysis of endometrial and ovarian cell lines reveals misidentification, redundancy and contamination.
Gynecol. Oncol. 127:241-248(2012)

PubMed=24023729; DOI=10.1371/journal.pone.0072162
Anglesio M.S., Wiegand K.C., Melnyk N., Chow C., Salamanca C.M., Prentice L.M., Senz J., Yang W., Spillman M.A., Cochrane D.R., Shumansky K., Shah S.P., Kalloger S.E., Huntsman D.G.
Type-specific cell line models for type-specific ovarian cancer research.
PLoS ONE 8:E72162-E72162(2013)

PubMed=25846456; DOI=10.3892/ijo.2015.2951
Takenaka M., Saito M., Iwakawa R., Yanaihara N., Saito M., Kato M., Ichikawa H., Shibata T., Yokota J., Okamoto A., Kohno T.
Profiling of actionable gene alterations in ovarian cancer by targeted deep sequencing.
Int. J. Oncol. 46:2389-2398(2015)

Cell line databases/resources MCCL; MCC:0000371
cancercelllines; CVCL_0473
Anatomy/cell type resources BTO; BTO:0003792
Biological sample resources BioSample; SAMN03151841
BioSample; SAMN03151843
Chemistry resources ChEMBL-Cells; CHEMBL3308015
ChEMBL-Targets; CHEMBL612818
PubChem_Cell_line; CVCL_0473
Encyclopedic resources Wikidata; Q54936825
Gene expression databases GEO; GSM184384
GEO; GSM184385
GEO; GSM659387
GEO; GSM711715
GEO; GSM711718
GEO; GSM851907
GEO; GSM851925
Polymorphism and mutation databases Cosmic; 849613
Cosmic; 948293
Cosmic; 988874
Cosmic; 1102825
Cosmic; 1524359
Cosmic; 1707563
Cosmic; 2582806
Cosmic; 2674703
IARC_TP53; 25074
Progenetix; CVCL_0473
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number31