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Cellosaurus PX2 (CVCL_W373)

[Text version]
Cell line name PX2
Accession CVCL_W373
Resource Identification Initiative To cite this cell line use: PX2 (RRID:CVCL_W373)
Comments Problematic cell line: Contaminated. Parent cell line (OV-2008) has been shown to be a ME-180 derivative.
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:45863; Paclitaxel (Taxol).
Transformant: NCBI_TaxID; 45240; Human papillomavirus type 68 (HPV68).
Derived from site: Metastatic; Omentum; UBERON=UBERON_0003688.
Sequence variations
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Human papillomavirus-related cervical squamous cell carcinoma (NCIt: C27676)
Squamous cell carcinoma of the cervix uteri (ORDO: Orphanet_213767)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0473 (OV-2008)
Sex of cell Female
Age at sampling 66Y
Category Cancer cell line
Publications

PubMed=21166887; DOI=10.1111/j.1749-0774.2010.00098.x
Nakajima K., Isonishi S., Saito M., Tachibana T., Ishikawa H.
Characterization of two independent, exposure-time dependent paclitaxel-resistant human ovarian carcinoma cell lines.
Hum. Cell 23:156-163(2010)

Cross-references
Cell line databases/resources cancercelllines; CVCL_W373
Encyclopedic resources Wikidata; Q54948745
Entry history
Entry creation16-Apr-2014
Last entry update05-Oct-2023
Version number16