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Cellosaurus MDCK-II (CVCL_0424)

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Cell line name MDCK-II
Synonyms MDCK II; MDCKII; MDCK2; MDCK-2; MDCK Type II; MDCKII-WT
Accession CVCL_0424
Resource Identification Initiative To cite this cell line use: MDCK-II (RRID:CVCL_0424)
Comments Group: Vaccine production cell line.
Omics: Deep proteome analysis.
Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
Cell type: Epithelial cell of kidney; CL=CL_0002518.
Species of origin Canis lupus familiaris (Dog) (Canis familiaris) (NCBI Taxonomy: 9615)
Breed/subspecies: Cocker Spaniel; VBO=VBO_0200372.
Hierarchy Parent: CVCL_0422 (MDCK)
Children:
CVCL_WY48 (MDCK-17)CVCL_ZW00 (MDCK-A3-10)CVCL_ZW01 (MDCK-A3-14)
CVCL_ZV47 (MDCK-A3-15)CVCL_B3SF (MDCK-II Abcc1)CVCL_A6UX (MDCK-II Rab10-KO)
CVCL_A6UY (MDCK-II Rab11-KO)CVCL_A6VA (MDCK-II Rab12-KO)CVCL_A6VB (MDCK-II Rab13-KO)
CVCL_A6VC (MDCK-II Rab14-KO)CVCL_A6VD (MDCK-II Rab15-KO)CVCL_A6VE (MDCK-II Rab17-KO)
CVCL_A6VF (MDCK-II Rab18-KO)CVCL_A6VG (MDCK-II Rab19-KO)CVCL_A6VI (MDCK-II Rab1A-KO)
CVCL_A6VJ (MDCK-II Rab1B-KO)CVCL_A6VK (MDCK-II Rab2-KO)CVCL_A6VL (MDCK-II Rab20-KO)
CVCL_A6VM (MDCK-II Rab21-KO)CVCL_A6VN (MDCK-II Rab22-KO)CVCL_A6VP (MDCK-II Rab23-KO)
CVCL_A6VQ (MDCK-II Rab24-KO)CVCL_A6VR (MDCK-II Rab25-KO)CVCL_A6VS (MDCK-II Rab26-KO)
CVCL_A6VU (MDCK-II Rab27-KO)CVCL_A6VV (MDCK-II Rab28-KO)CVCL_A6VW (MDCK-II Rab29-KO)
CVCL_A6VX (MDCK-II Rab3-KO)CVCL_A6VY (MDCK-II Rab30-KO)CVCL_A6VZ (MDCK-II Rab32/38-KO)
CVCL_A6WA (MDCK-II Rab33-KO)CVCL_A6WB (MDCK-II Rab34-KO)CVCL_A6WD (MDCK-II Rab35-KO)
CVCL_A6WE (MDCK-II Rab36-KO)CVCL_A6WF (MDCK-II Rab37-KO)CVCL_A6WG (MDCK-II Rab39-KO)
CVCL_A6WI (MDCK-II Rab4-KO)CVCL_A6WJ (MDCK-II Rab40-KO)CVCL_A6WK (MDCK-II Rab42-KO)
CVCL_A6WL (MDCK-II Rab43-KO)CVCL_A6WM (MDCK-II Rab5AB-KO)CVCL_A6WN (MDCK-II Rab5C-KO)
CVCL_A6WP (MDCK-II Rab6-KO)CVCL_A6WQ (MDCK-II Rab7A-KO)CVCL_A6WV (MDCK-II Rab7AB-KO)
CVCL_A6WR (MDCK-II Rab7B-KO)CVCL_A6WS (MDCK-II Rab8-KO)CVCL_A6WT (MDCK-II Rab9-KO)
CVCL_S586 (MDCK-MDR1)CVCL_X022 (MDCK-MRP2)CVCL_A2JZ (MDCK2-ABCB1)
CVCL_A2JY (MDCK2-ABCC2)CVCL_C3F0 (MDCKII MDR1 KO)CVCL_VR40 (MDCKII-LE)
Sex of cell Female
Age at sampling Adult
Category Spontaneously immortalized cell line
Publications

PubMed=1468552; DOI=10.1016/0014-5793(92)81476-3
Grunberg J., Luginbuhl U., Sterchi E.E.
Proteolytic processing of human intestinal lactase-phlorizin hydrolase precursor is not a prerequisite for correct sorting in Madin Darby canine kidney (MDCK) cells.
FEBS Lett. 314:224-228(1992)

PubMed=19941903; DOI=10.1016/j.jviromet.2009.11.022
Karger A., Bettin B., Lenk M., Mettenleiter T.C.
Rapid characterisation of cell cultures by matrix-assisted laser desorption/ionisation mass spectrometric typing.
J. Virol. Methods 164:116-121(2010)

PubMed=21766308; DOI=10.1002/jps.22674
Di L., Whitney-Pickett C., Umland J.P., Zhang H., Zhang X., Gebhard D.F., Lai Y.-R., Federico J.J. 3rd, Davidson R.E., Smith R., Reyner E.L., Lee C., Feng B., Rotter C., Varma M.V., Kempshall S., Fenner K., El-Kattan A.F., Liston T.E., Troutman M.D.
Development of a new permeability assay using low-efflux MDCKII cells.
J. Pharm. Sci. 100:4974-4985(2011)

PubMed=21982418; DOI=10.1186/1471-2121-12-43; PMCID=PMC3209442
Dukes J.D., Whitley P., Chalmers A.D.
The MDCK variety pack: choosing the right strain.
BMC Cell Biol. 12:43.1-43.4(2011)

PubMed=24975811; DOI=10.1016/j.vaccine.2014.06.045; PMCID=PMC5915289
Donis R.O., Chen L.-M., Davis C.T., Foust A., Hossain M.J., Johnson A., Klimov A., Loughlin R.F., Xu X.-Y., Tsai T., Blayer S., Trusheim H., Colegate T., Fox J., Taylor B., Hussain A.I., Barr I., Baas C., Louwerens J., Geuns E., Lee M.-S., Venhuizen L., Neumeier E., Ziegler T.
Influenza Cell Culture Working Group
Performance characteristics of qualified cell lines for isolation and propagation of influenza viruses for vaccine manufacturing.
Vaccine 32:6583-6590(2014)

PubMed=34737324; DOI=10.1038/s41598-021-00779-5; PMCID=PMC8569163
Lung O., Candlish R.C., Nebroski M., Kruckiewicz P., Buchanan C., Moniwa M.
High-throughput sequencing for species authentication and contamination detection of 63 cell lines.
Sci. Rep. 11:21657-21657(2021)

Cross-references
Cell line collections (Providers) AddexBio; P0014001/82
CCLV; CCLV-RIE 1061
ECACC; 00062107
RCB; RCB5148
Cell line databases/resources MCCL; MCC:0000321
Lonza; 811
Anatomy/cell type resources BTO; BTO:0004607
Chemistry resources ChEMBL-Cells; CHEMBL3308862
ChEMBL-Targets; CHEMBL4296466
PubChem_Cell_line; CVCL_0424
Encyclopedic resources Wikidata; Q54904781
Proteomic databases PRIDE; PXD001130
Entry history
Entry creation04-Apr-2012
Last entry update10-Sep-2024
Version number22