Cellosaurus cell line MDCKII-LE (CVCL

Cross-references
Cell line name	MDCKII-LE
Synonyms	MDCKII-Low Efflux; RRCK; Ralph Russ Canine Kidney
Accession	CVCL_VR40
Resource Identification Initiative	To cite this cell line use: MDCKII-LE (RRID:CVCL_VR40)
Comments	Characteristics: Compared to the parent cell line, has a lower expression of endogenous ABCB1/MDR1. Derived from site: In situ; Kidney; UBERON=UBERON_0002113. Cell type: Epithelial cell of kidney; CL=CL_0002518.
Species of origin	Canis lupus familiaris (Dog) (Canis familiaris) (NCBI Taxonomy: 9615) Breed/subspecies: Cocker Spaniel; VBO=VBO_0200372.
Hierarchy	Parent: CVCL_0424 (MDCK-II)
Sex of cell	Female
Age at sampling	Adult
Category	Spontaneously immortalized cell line
Publications	PubMed=21766308; DOI=10.1002/jps.22674 Di L., Whitney-Pickett C., Umland J.P., Zhang H., Zhang X., Gebhard D.F., Lai Y.-R., Federico J.J. 3rd, Davidson R.E., Smith R., Reyner E.L., Lee C., Feng B., Rotter C., Varma M.V., Kempshall S., Fenner K., El-Kattan A.F., Liston T.E., Troutman M.D. Development of a new permeability assay using low-efflux MDCKII cells. J. Pharm. Sci. 100:4974-4985(2011)
Chemistry resources	ChEMBL-Cells; CHEMBL4295481 ChEMBL-Targets; CHEMBL4296468 PubChem_Cell_line; CVCL_VR40
Encyclopedic resources	Wikidata; Q95987829
Entry history
Entry creation	13-Nov-2018
Last entry update	10-Sep-2024
Version number	8