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Cellosaurus MDCK-MRP2 (CVCL_X022)

[Text version]
Cell line name MDCK-MRP2
Synonyms MDCKII-MRP2; MDCKII-MOAT17
Accession CVCL_X022
Resource Identification Initiative To cite this cell line use: MDCK-MRP2 (RRID:CVCL_X022)
Comments Genetic integration: Method=Transfection; Gene=HGNC; 53; ABCC2.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Caution: There is another MDCK-II cell line with transfected human ABCC2: MDCK2-ABCC2 (Cellosaurus=CVCL_A2JY).
Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
Cell type: Epithelial cell of kidney; CL=CL_0002518.
Species of origin Canis lupus familiaris (Dog) (Canis familiaris) (NCBI Taxonomy: 9615)
Breed/subspecies: Cocker Spaniel; VBO=VBO_0200372.
Hierarchy Parent: CVCL_0424 (MDCK-II)
Children:
CVCL_9U72 (MDCKII-MRP2/UGT1A1)
Sex of cell Female
Age at sampling Adult
Category Spontaneously immortalized cell line
Publications

PubMed=9525973; DOI=10.1172/JCI119886; PMCID=PMC508708
Evers R., Kool M., van Deemter L., Janssen H., Calafat J., Oomen L.C.J.M., Paulusma C.C., Oude Elferink R.P.J., Baas F., Schinkel A.H., Borst P.
Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA.
J. Clin. Invest. 101:1310-1319(1998)

PubMed=12134946; DOI=10.1023/A:1016192413308
Tang F.-X., Horie K., Borchardt R.T.
Are MDCK cells transfected with the human MRP2 gene a good model of the human intestinal mucosa?
Pharm. Res. 19:773-779(2002)

Cross-references
Encyclopedic resources Wikidata; Q54904784
Entry history
Entry creation17-Jul-2014
Last entry update10-Sep-2024
Version number12