| Cell line name |
MOC2 |
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| Synonyms |
Mouse Oral Cancer 2 |
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| Accession |
CVCL_ZD33 |
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| Resource Identification Initiative |
To cite this cell line use: MOC2 (RRID:CVCL_ZD33) |
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| Comments |
Characteristics: Agressive growth phenotype.
Transformant: ChEBI; CHEBI:254496; 7,12-dimethyltetraphene (DMBA; dimethylbenzanthracene).
Omics: Deep exome analysis.
Omics: Transcriptome analysis by microarray. |
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| Sequence variations |
- Mutation; MGI; MGI:96680; Kras; Simple; p.Gln61His (c.183A>T); Zygosity=Unspecified (PubMed=22086849).
- Mutation; MGI; MGI:98834; Trp53; Simple; p.Glu225Ter; Zygosity=Unspecified (PubMed=24668645).
|
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| Disease |
Squamous cell carcinoma of the mouse oral cavity (NCIt: C23049) |
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| Species of origin |
Mus musculus (Mouse)
(NCBI Taxonomy: 10090)
Breed/subspecies: C57BL/6 Cxcr3-/-. |
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| Hierarchy |
Children:
|
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| Originate from same individual |
CVCL_ZD38 ! MOC2LN |
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| Sex of cell |
Female |
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| Category |
Cancer cell line |
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| STR profile |
Source(s): Kerafast=EWL002-FP; Millipore=SCC470
Markers:| Mouse STR 1-1 | 16 |
| Mouse STR 1-2 | 18,19 |
| Mouse STR 2-1 | 16 |
| Mouse STR 3-2 | 14 |
| Mouse STR 4-2 | 20.3 |
| Mouse STR 5-5 | 17 |
| Mouse STR 6-4 | 18 |
| Mouse STR 6-7 | 15 (Kerafast=EWL002-FP)
15,16 (Millipore=SCC470) |
| Mouse STR 7-1 | 26.2 |
| Mouse STR 8-1 | 16 |
| Mouse STR 11-2 | 16 |
| Mouse STR 12-1 | 17 |
| Mouse STR 13-1 | 17 |
| Mouse STR 15-3 | 22.3,23.3 |
| Mouse STR 17-2 | 15 |
| Mouse STR 18-3 | 17 |
| Mouse STR 19-2 | 13 |
| Mouse STR X-1 | 26 |
Run an STR similarity search on this cell line |
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| Publications | PubMed=22086849; DOI=10.1158/0008-5472.CAN-11-1831; PMCID=PMC3286642
Judd N.P., Winkler A.E., Murillo-Sauca O., Brotman J.J., Law J.H., Lewis J.S. Jr., Dunn G.P., Bui J.D., Sunwoo J.B., Uppaluri R.
ERK1/2 regulation of CD44 modulates oral cancer aggressiveness.
Cancer Res. 72:365-374(2012) PubMed=22434099; DOI=10.1177/0194599812442037; PMCID=PMC6346425
Judd N.P., Allen C.T., Winkler A.E., Uppaluri R.
Comparative analysis of tumor-infiltrating lymphocytes in a syngeneic mouse model of oral cancer.
Otolaryngol. Head Neck Surg. 147:493-500(2012) PubMed=24668645; DOI=10.1158/1078-0432.CCR-14-0205; PMCID=PMC4096804
Onken M.D., Winkler A.E., Kanchi K.-L., Chalivendra V., Law J.H., Rickert C.G., Kallogjeri D., Judd N.P., Dunn G.P., Piccirillo J.F., Lewis J.S. Jr., Mardis E.R., Uppaluri R.
A surprising cross-species conservation in the genomic landscape of mouse and human oral cancer identifies a transcriptional signature predicting metastatic disease.
Clin. Cancer Res. 20:2873-2884(2014) PubMed=25729643; DOI=10.1016/j.gdata.2014.11.006; PMCID=PMC4340082
Chalivendra V., Kanchi K.-L., Onken M.D., Winkler A.E., Mardis E.R., Uppaluri R.
Genomic analysis to define molecular basis of aggressiveness in a mouse model of oral cancer.
Genom. Data 3:61-62(2015) |
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| Cross-references |
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| Cell line collections (Providers) |
Kerafast; EWL002-FP
Millipore; SCC470
|
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| Encyclopedic resources |
Wikidata; Q98127271
|
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| Gene expression databases |
GEO; GSM1213080
GEO; GSM1213081
GEO; GSM1213082
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| Entry history |
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| Entry creation | 02-Jul-2020 |
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| Last entry update | 10-Sep-2024 |
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| Version number | 7 |
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