Cellosaurus cell line MOC2-7 (CVCL

Cellosaurus MOC2-7 (CVCL_ZD34)

Cross-references
Cell line name	MOC2-7
Synonyms	MOC7; Mouse Oral Cancer 7
Accession	CVCL_ZD34
Resource Identification Initiative	To cite this cell line use: MOC2-7 (RRID:CVCL_ZD34)
Comments	Problematic cell line: Contaminated. Shown to be a MOC2 derivative (PubMed=24668645). Originally (PubMed=22086849) thought to be independently derived and was named MOC7. Was renamed MOC2-7 when shown to be a derivative of MOC2. Transformant: ChEBI; CHEBI:59032; 7,12-dimethyltetraphene (DMBA; dimethylbenzanthracene). Omics: Transcriptome analysis by microarray.
Sequence variations	Mutation; MGI; MGI:96680; Kras; Simple; p.Gln61His (c.183A>T); Zygosity=Unspecified (PubMed=22086849). Mutation; MGI; MGI:98834; Trp53; Simple; p.Glu225Ter; Zygosity=Unspecified (from parent cell line).
Disease	Squamous cell carcinoma of the mouse oral cavity (NCIt: C23049)
Species of origin	Mus musculus (Mouse) (NCBI Taxonomy: 10090) Breed/subspecies: C57BL/6 Cxcr3-/-.
Hierarchy	Parent: CVCL_ZD33 (MOC2)
Sex of cell	Female
Category	Cancer cell line
Publications	PubMed=22086849; DOI=10.1158/0008-5472.CAN-11-1831 Judd N.P., Winkler A.E., Murillo-Sauca O., Brotman J.J., Law J.H., Lewis J.S. Jr., Dunn G.P., Bui J.D., Sunwoo J.B., Uppaluri R. ERK1/2 regulation of CD44 modulates oral cancer aggressiveness. Cancer Res. 72:365-374(2012) PubMed=24668645; DOI=10.1158/1078-0432.CCR-14-0205 Onken M.D., Winkler A.E., Kanchi K.-L., Chalivendra V., Law J.H., Rickert C.G., Kallogjeri D., Judd N.P., Dunn G.P., Piccirillo J.F., Lewis J.S. Jr., Mardis E.R., Uppaluri R. A surprising cross-species conservation in the genomic landscape of mouse and human oral cancer identifies a transcriptional signature predicting metastatic disease. Clin. Cancer Res. 20:2873-2884(2014) PubMed=25729643; DOI=10.1016/j.gdata.2014.11.006 Chalivendra V., Kanchi K.-L., Onken M.D., Winkler A.E., Mardis E.R., Uppaluri R. Genomic analysis to define molecular basis of aggressiveness in a mouse model of oral cancer. Genomics Data 3:61-62(2015)
Encyclopedic resources	Wikidata; Q98127273
Gene expression databases	GEO; GSM1213083 GEO; GSM1213084 GEO; GSM1213085
Entry history
Entry creation	02-Jul-2020
Last entry update	21-Mar-2023
Version number	4