Cell line name |
LNCaP-95 |
Synonyms |
LNCaP 95; LNCaP95; LN95 |
Accession |
CVCL_ZC87 |
Resource Identification Initiative |
To cite this cell line use: LNCaP-95 (RRID:CVCL_ZC87) |
Comments |
Population: Caucasian. Characteristics: Androgen-independent. Doubling time: 52.2 hours (PubMed=32954481). Derived from site: Metastatic; Left supraclavicular lymph node; UBERON=UBERON_8480056. |
Sequence variations |
- Mutation; HGNC; HGNC:644; AR; Simple; p.Thr878Ala (c.2632A>G); ClinVar=VCV000009831; Zygosity=Hemizygous (PubMed=28928128).
- Mutation; HGNC; HGNC:7010; MEN1; Simple; p.Tyr318Ter (c.954T>G) (p.Tyr313Ter, c.939T>A); ClinVar=VCV000439894; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:8979; PIK3R1; Simple; p.Arg639Ter (c.1915C>T); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys6Argfs*4 (c.17_18delAA); ClinVar=VCV000231649; Zygosity=Unspecified (from parent cell line).
|
Disease |
Prostate carcinoma (NCIt: C4863) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_1379 (LNCaP clone FGC) Children:
|
Sex of cell |
Male |
Age at sampling |
50Y |
Category |
Cancer cell line |
Publications | PubMed=10420156; DOI=10.1002/(SICI)1097-0045(19990901)40:4<269::AID-PROS9>3.0.CO;2-6 Pflug B.R., Reiter R.E., Nelson J.B. Caveolin expression is decreased following androgen deprivation in human prostate cancer cell lines. Prostate 40:269-273(1999) PubMed=28928128; DOI=10.1158/0008-5472.CAN-17-0320; PMCID=PMC5654612 Van Etten J.L., Nyquist M.D., Li Y.-M., Yang R.-D., Ho Y., Johnson R., Ondigi O., Voytas D.F., Henzler C., Dehm S.M. Targeting a single alternative polyadenylation site coordinately blocks expression of androgen receptor mRNA splice variants in prostate cancer. Cancer Res. 77:5228-5235(2017) PubMed=32954481; DOI=10.1007/s13577-020-00435-6; PMCID=PMC8693726 Leung J.K., Tam T., Wang J., Sadar M.D. Isolation and characterization of castration-resistant prostate cancer LNCaP95 clones. Hum. Cell 34:211-218(2021) PubMed=38892296; DOI=10.3390/ijms25116111; PMCID=PMC11172770 Beatson E.L., Risdon E.N., Napoli G.C., Price D.K., Chau C.H., Figg W.D. Sr. Genomic characterization of preclinical prostate cancer cell line models. Int. J. Mol. Sci. 25:6111.1-6111.19(2024) |
Cross-references |
Cell line databases/resources |
cancercelllines; CVCL_ZC87
|
Anatomy/cell type resources |
BTO; BTO_0006264
|
Encyclopedic resources |
Wikidata; Q98126929
|
Entry history |
Entry creation | 02-Jul-2020 |
Last entry update | 19-Dec-2024 |
Version number | 9 |
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