ID   LNCaP-95
AC   CVCL_ZC87
SY   LNCaP 95; LNCaP95; LN95
DR   BTO; BTO:0006264
DR   cancercelllines; CVCL_ZC87
DR   Wikidata; Q98126929
RX   PubMed=10420156;
RX   PubMed=28928128;
RX   PubMed=32954481;
CC   Population: Caucasian.
CC   Characteristics: Androgen-independent.
CC   Doubling time: 52.2 hours (PubMed=32954481).
CC   Sequence variation: Mutation; HGNC; 644; AR; Simple; p.Thr878Ala (c.2632A>G); ClinVar=VCV000009831; Zygosity=Hemizygous (PubMed=28928128).
CC   Sequence variation: Mutation; HGNC; 7010; MEN1; Simple; p.Tyr318Ter (c.954T>G) (p.Tyr313Ter, c.939T>A); ClinVar=VCV000439894; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8979; PIK3R1; Simple; p.Arg639Ter (c.1915C>T); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9588; PTEN; Simple; p.Lys6Argfs*4 (c.17_18delAA); ClinVar=VCV000231649; Zygosity=Unspecified (from parent cell line).
CC   Derived from site: Metastatic; Left supraclavicular lymph node; UBERON=UBERON_8480056.
DI   NCIt; C4863; Prostate carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1379 ! LNCaP clone FGC
SX   Male
AG   50Y
CA   Cancer cell line
DT   Created: 02-07-20; Last updated: 05-10-23; Version: 8
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RX   PubMed=10420156; DOI=10.1002/(SICI)1097-0045(19990901)40:4<269::AID-PROS9>3.0.CO;2-6;
RA   Pflug B.R., Reiter R.E., Nelson J.B.;
RT   "Caveolin expression is decreased following androgen deprivation in
RT   human prostate cancer cell lines.";
RL   Prostate 40:269-273(1999).
//
RX   PubMed=28928128; DOI=10.1158/0008-5472.CAN-17-0320; PMCID=PMC5654612;
RA   Van Etten J.L., Nyquist M.D., Li Y.-M., Yang R.-D., Ho Y., Johnson R.,
RA   Ondigi O., Voytas D.F., Henzler C., Dehm S.M.;
RT   "Targeting a single alternative polyadenylation site coordinately
RT   blocks expression of androgen receptor mRNA splice variants in
RT   prostate cancer.";
RL   Cancer Res. 77:5228-5235(2017).
//
RX   PubMed=32954481; DOI=10.1007/s13577-020-00435-6; PMCID=PMC8693726;
RA   Leung J.K., Tam T., Wang J., Sadar M.D.;
RT   "Isolation and characterization of castration-resistant prostate
RT   cancer LNCaP95 clones.";
RL   Hum. Cell 34:211-218(2021).
//