ID   C2BBe2
AC   CVCL_Z582
SY   C2BBe 2; Caco-2/BBe 2; Caco-2 Brush Border expressing 2
DR   cancercelllines; CVCL_Z582
DR   Wikidata; Q54808118
RX   PubMed=1506435;
RX   PubMed=15868485;
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; 583; APC; Simple; p.Gln1367Ter (c.4099C>T); ClinVar=VCV000376060; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 2514; CTNNB1; Simple; p.Gly245Ala (c.734G>C); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6770; SMAD4; Simple; p.Asp351His (c.1051G>C); ClinVar=VCV000375998; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Glu204Ter (c.610G>T); ClinVar=VCV000977783; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0025 ! Caco-2
SX   Male
AG   72Y
CA   Cancer cell line
DT   Created: 10-04-15; Last updated: 05-10-23; Version: 13
//
RX   PubMed=1506435; DOI=10.1242/jcs.102.3.581;
RA   Peterson M.D., Mooseker M.S.;
RT   "Characterization of the enterocyte-like brush border cytoskeleton of
RT   the C2BBe clones of the human intestinal cell line, Caco-2.";
RL   J. Cell Sci. 102:581-600(1992).
//
RX   PubMed=15868485; DOI=10.1007/s10565-005-0085-6;
RA   Sambuy Y., De Angelis I., Ranaldi G., Scarino M.L., Stammati A.,
RA   Zucco F.;
RT   "The Caco-2 cell line as a model of the intestinal barrier: influence
RT   of cell and culture-related factors on Caco-2 cell functional
RT   characteristics.";
RL   Cell Biol. Toxicol. 21:1-26(2005).
//