ID   CC-M2
AC   CVCL_Y097
DR   BCRC; 60449
DR   cancercelllines; CVCL_Y097
DR   Wikidata; Q54808712
RX   PubMed=1696674;
RX   PubMed=15144569;
WW   http://www.bcrc.firdi.org.tw/attach/2019-05-28/a.pdf
CC   Problematic cell line: Contaminated. Shown to be a SW480 (or SW620) derivative (BCRC=60449). Originally thought to originate from a 58 year old male patient with a sigmoid colorectal carcinoma.
CC   Population: Caucasian.
CC   Doubling time: 20.0 hours (Note=At 25th passage), 18.5 hours (Note=At 50th passage) (PubMed=1696674).
CC   Sequence variation: Mutation; HGNC; 583; APC; Simple; p.Gln1338Ter (c.4012C>T); ClinVar=VCV000000801; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012583; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Pro309Ser (c.925C>T); ClinVar=VCV000458575; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Ser227Phe (c.680C>T); Zygosity=Unspecified (PubMed=15144569).
CC   Discontinued: BCRC; 60449; true.
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0546 ! SW480
SX   Male
AG   51Y
CA   Cancer cell line
DT   Created: 07-11-14; Last updated: 30-01-24; Version: 13
//
RX   PubMed=1696674; DOI=10.1002/jso.2930440414;
RA   Cheng J.-Y., Meng C.-L., Lin J.-C., Tzeng C.-C., Chin L.-T.,
RA   Shen K.-L.;
RT   "Characterization of four newly established human colorectal
RT   adenocarcinoma cell lines from Chinese patients.";
RL   J. Surg. Oncol. 44:260-267(1990).
//
RX   PubMed=15144569; DOI=10.1089/107999004323034105;
RA   Juang S.-H., Wei S.-J., Hung Y.-M., Hsu C.-Y., Yang D.-M., Liu K.-J.,
RA   Chen W.-S., Yang W.K.;
RT   "IFN-beta induces caspase-mediated apoptosis by disrupting
RT   mitochondria in human advanced stage colon cancer cell lines.";
RL   J. Interferon Cytokine Res. 24:231-243(2004).
//