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Cellosaurus UTA6 (CVCL_XF79)

[Text version]
Cell line name UTA6
Synonyms UTA 6
Accession CVCL_XF79
Resource Identification Initiative To cite this cell line use: UTA6 (RRID:CVCL_XF79)
Comments Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P04483; Escherichia coli Tn10 tetR.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Derived from site: In situ; Bone, tibia; UBERON=UBERON_0000979.
Sequence variations
  • Mutation; HGNC; 9277; PPM1D; Simple; p.Arg458Ter (c.1372C>T); ClinVar=VCV002445214; Zygosity=Heterozygous (from parent cell line).
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0042 (U2OS)
Children:
CVCL_XF82 (UTA21.15)CVCL_XF83 (UTA21.9)
Sex of cell Female
Age at sampling 15Y
Category Cancer cell line
Publications

PubMed=7588596; DOI=10.1002/j.1460-2075.1995.tb00148.x; PMCID=PMC394563
Englert C., Hou X.-Y., Maheswaran S., Bennett P., Ngwu C., Re G.G., Garvin A.J., Rosner M.R., Haber D.A.
WT1 suppresses synthesis of the epidermal growth factor receptor and induces apoptosis.
EMBO J. 14:4662-4675(1995)

PubMed=9484832; DOI=10.1038/sj.onc.1201558
Medema R.H., Klompmaker R., Smits V.A.J., Rijksen G.
p21waf1 can block cells at two points in the cell cycle, but does not interfere with processive DNA-replication or stress-activated kinases.
Oncogene 16:431-441(1998)

Cross-references
Encyclopedic resources Wikidata; Q98134398
Entry history
Entry creation06-Sep-2019
Last entry update10-Sep-2024
Version number9