ID   HT-29/SN-38
AC   CVCL_WV61
DR   cancercelllines; CVCL_WV61
DR   Wikidata; Q94304661
RX   PubMed=23546019;
CC   Population: Caucasian.
CC   Doubling time: 30 hours (PubMed=23546019).
CC   Selected for resistance to: ChEBI; CHEBI:8988; SN-38 (7-ethyl-10-hydroxy-camptothecin).
CC   Sequence variation: Mutation; HGNC; 583; APC; Simple; p.Glu853Ter (c.2557G>T); ClinVar=VCV001071632; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 583; APC; Simple; p.Thr1556Asnfs*3 (c.4666dupA) (c.4666_4667insA); ClinVar=VCV000428112; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Pro449Thr (c.1345C>A); ClinVar=VCV001333250; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6770; SMAD4; Simple; p.Gln311Ter (c.931C>T); ClinVar=VCV000230663; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0320 ! HT-29
SX   Female
AG   44Y
CA   Cancer cell line
DT   Created: 05-07-19; Last updated: 05-10-23; Version: 10
//
RX   PubMed=23546019; DOI=10.3892/ijo.2013.1868;
RA   Petitprez A., Poindessous V., Ouaret D., Regairaz M., Bastian G.,
RA   Guerin E., Escargueil A.E., Larsen A.K.;
RT   "Acquired irinotecan resistance is accompanied by stable modifications
RT   of cell cycle dynamics independent of MSI status.";
RL   Int. J. Oncol. 42:1644-1653(2013).
//