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Cellosaurus HCC1954-TGL (CVCL_VR24)

[Text version]
Cell line name HCC1954-TGL
Synonyms HCC1954-HSV1-TK/GFP/Fluc
Accession CVCL_VR24
Resource Identification Initiative To cite this cell line use: HCC1954-TGL (RRID:CVCL_VR24)
Comments Population: East Indian.
Characteristics: Transfected with HSV1-TK/GFP/Fluc (TGL) and with PuroR/pac.
Genetic integration: Method=Transfection/transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P08659; Firefly luciferase.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; Q9QNF7; Human herpesvirus 1 TK.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
Omics: H3K27ac ChIP-seq epigenome analysis.
Omics: Transcriptome analysis by RNAseq.
Miscellaneous: STR profile from MSKCC antibody and bioresource core facility.
Caution: In PubMed=27015306, PubMed=28283064 and the associated GEO data sets HCC1954-TGL is termed HCC1954 Parental.
Derived from site: In situ; Breast; UBERON=UBERON_0000310.
Sequence variations
  • Gene fusion; HGNC; 2092; CLTC + HGNC; 29559; VMP1; Name(s)=CLTC-VMP1 (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Tyr163Cys (c.488A>G); ClinVar=VCV000127814; Zygosity=Homozygous (from parent cell line).
Disease Breast ductal carcinoma (NCIt: C4017)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1259 (HCC1954)
Children:
CVCL_VR25 (HCC1954-LCC1)CVCL_XA23 (HCC1954-LeptoM)
Sex of cell Female
Age at sampling 61Y
Category Cancer cell line
STR profile Source(s): MSKCC

Markers:
AmelogeninX
CSF1PO10
D2S133817,26
D3S135815,16
D5S81811
D7S82010,11
D8S117912,15
D13S3178,9
D16S5399,11
D18S5114,18
D19S43313,15.2
D21S1128,32.2
FGA22,23
TH016,7
TPOX8,9
vWA18,19

Run an STR similarity search on this cell line
Publications

PubMed=27015306; DOI=10.1016/j.cell.2016.02.025; PMCID=PMC4808520
Malladi S., Macalinao D.G., Jin X., He L., Basnet H., Zou Y.-L., de Stanchina E., Massague J.
Metastatic latency and immune evasion through autocrine inhibition of WNT.
Cell 165:45-60(2016)

PubMed=28283064; DOI=10.1016/j.cell.2017.02.025; PMCID=PMC5405733
Boire A., Zou Y.-L., Shieh J., Macalinao D.G., Pentsova E., Massague J.
Complement component 3 adapts the cerebrospinal fluid for leptomeningeal metastasis.
Cell 168:1101-1113.e13(2017)

Cross-references
Cell line databases/resources cancercelllines; CVCL_VR24
Encyclopedic resources Wikidata; Q93982624
Gene expression databases GEO; GSM1875307
GEO; GSM1875308
GEO; GSM1875309
GEO; GSM1875314
GEO; GSM1875315
GEO; GSM1875316
GEO; GSM2066431
GEO; GSM2066435
GEO; GSM2066439
GEO; GSM2194085
GEO; GSM2194086
GEO; GSM2194087
Entry history
Entry creation13-Nov-2018
Last entry update10-Sep-2024
Version number12