ID   HCC1954-TGL
AC   CVCL_VR24
SY   HCC1954-HSV1-TK/GFP/Fluc
DR   cancercelllines; CVCL_VR24
DR   GEO; GSM1875307
DR   GEO; GSM1875308
DR   GEO; GSM1875309
DR   GEO; GSM1875314
DR   GEO; GSM1875315
DR   GEO; GSM1875316
DR   GEO; GSM2066431
DR   GEO; GSM2066435
DR   GEO; GSM2066439
DR   GEO; GSM2194085
DR   GEO; GSM2194086
DR   GEO; GSM2194087
DR   Wikidata; Q93982624
RX   PubMed=27015306;
RX   PubMed=28283064;
CC   Population: East Indian.
CC   Characteristics: Transfected with HSV1-TK/GFP/Fluc (TGL) and with PuroR/pac.
CC   Sequence variation: Gene fusion; HGNC; 2092; CLTC + HGNC; 29559; VMP1; Name(s)=CLTC-VMP1 (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Tyr163Cys (c.488A>G); ClinVar=VCV000127814; Zygosity=Homozygous (from parent cell line).
CC   Transfected with: UniProtKB; P42212; GFP (with p.Phe64Leu, p.Ser65Thr and p.His231Leu = EGFP).
CC   Transfected with: UniProtKB; P08659; Firefly luciferase.
CC   Transfected with: UniProtKB; Q9QNF7; Human herpesvirus 1 TK.
CC   Transfected with: UniProtKB; P13249; S.alboniger pac (PuroR).
CC   Omics: H3K27ac ChIP-seq epigenome analysis.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Miscellaneous: STR profile from MSKCC antibody and bioresource core facility.
CC   Caution: In PubMed=27015306, PubMed=28283064 and the associated GEO data sets HCC1954-TGL is termed HCC1954 Parental.
CC   Derived from site: In situ; Breast; UBERON=UBERON_0000310.
ST   Source(s): MSKCC
ST   Amelogenin: X
ST   CSF1PO: 10
ST   D13S317: 8,9
ST   D16S539: 9,11
ST   D18S51: 14,18
ST   D19S433: 13,15.2
ST   D21S11: 28,32.2
ST   D2S1338: 17,26
ST   D3S1358: 15,16
ST   D5S818: 11
ST   D7S820: 10,11
ST   D8S1179: 12,15
ST   FGA: 22,23
ST   TH01: 6,7
ST   TPOX: 8,9
ST   vWA: 18,19
DI   NCIt; C4017; Breast ductal carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1259 ! HCC1954
SX   Female
AG   61Y
CA   Cancer cell line
DT   Created: 13-11-18; Last updated: 05-10-23; Version: 11
//
RX   PubMed=27015306; DOI=10.1016/j.cell.2016.02.025;
RA   Malladi S., Macalinao D.G., Jin X., He L., Basnet H., Zou Y.-L.,
RA   de Stanchina E., Massague J.;
RT   "Metastatic latency and immune evasion through autocrine inhibition of
RT   WNT.";
RL   Cell 165:45-60(2016).
//
RX   PubMed=28283064; DOI=10.1016/j.cell.2017.02.025;
RA   Boire A., Zou Y.-L., Shieh J., Macalinao D.G., Pentsova E.,
RA   Massague J.;
RT   "Complement component 3 adapts the cerebrospinal fluid for
RT   leptomeningeal metastasis.";
RL   Cell 168:1101-1113.e13(2017).
//