ID   ELD-1 C-8
AC   CVCL_VN22
SY   ELD-1 subclone C-8; C-8
DR   Wikidata; Q93539956
RX   DOI=10.14930/jsma1939.62.310;
RX   PubMed=15922715;
CC   Problematic cell line: Contaminated. Ancestral cell line (MOBS-1) has been shown to be a U-937 derivative.
CC   Population: Caucasian.
CC   Sequence variation: Gene fusion; HGNC; 16063; MLLT10 + HGNC; 15514; PICALM; Name(s)=PICALM-MLLT10, CALM-AF10 (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9588; PTEN; Simple; p.Gly129fs*51 (c.387_388insCGCC); Zygosity=Hemizygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9644; PTPN11; Simple; p.Gly60Arg (c.178G>C); ClinVar=VCV000372590; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; c.559+1G>A (p.Val173Trpfs*59); ClinVar=VCV000428908; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 12796; WT1; Simple; p.Arg301Ter (c.901C>T) (p.Arg352Ter, c.1054C>T) (p.Arg374Ter, c.1120C>T); ClinVar=VCV000449416; Zygosity=Heterozygous (from parent cell line).
CC   Derived from sampling site: Pleural effusion.
DI   NCIt; C8263; Adult acute monocytic leukemia
DI   ORDO; Orphanet_514; Acute monoblastic/monocytic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_VN20 ! ELD-1
SX   Male
AG   37Y
CA   Cancer cell line
DT   Created: 07-09-18; Last updated: 21-03-23; Version: 8
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RX   DOI=10.14930/jsma1939.62.310;
RA   Tamaoki S., Iwamoto S., Ishida M., Sugisaki K., Nakamura K.;
RT   "Roles of cytokines in interferon-gamma; generation by allogeneic
RT   response between CD8 T cells and a human dendritic cell-like cell
RT   line, ELD-1 -- a model of study for CD8 T cell promotion independent
RT   helper T cells.";
RL   Showa Igakkai Zasshi 62:310-320(2002).
//
RX   PubMed=15922715; DOI=10.1016/j.cellimm.2005.01.008;
RA   Iwamoto S., Ishida M., Tamaoki S., Hagiwara T., Sueki H., Miyazaki A.;
RT   "A human Langerhans cell-like cell line, ELD-1, promotes CD8 T cells
RT   to produce IFN-gamma through CD70-dependent alternative pathway.";
RL   Cell. Immunol. 232:49-56(2004).
//