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Cellosaurus N (CVCL_UZ57)

[Text version]
Cell line name N
Synonyms Strain N
Accession CVCL_UZ57
Resource Identification Initiative To cite this cell line use: N (RRID:CVCL_UZ57)
Comments Senescence: Senesces at ~52-55 PDL (PubMed=10648628; PubMed=12077343).
Derived from site: In situ; Skin, epidermis; UBERON=UBERON_0001003.
Cell type: Keratinocyte; CL=CL_0000312.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_UZ60 (N/bmi1/TERT)CVCL_UZ61 (N/E6E7)CVCL_CW92 (N/TERT-1)
CVCL_UZ62 (N/TERT-2)
Sex of cell Male
Age at sampling <1M
Category Finite cell line
Web pages https://dermatology.bwh.harvard.edu/docs/Cell-Culture-Core-Cell-Lines.pdf
Publications

PubMed=10648628; DOI=10.1128/mcb.20.4.1436-1447.2000; PMCID=PMC85304
Dickson M.A., Hahn W.C., Ino Y., Ronfard V., Wu J.Y., Weinberg R.A., Louis D.N., Li F.P., Rheinwald J.G.
Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics.
Mol. Cell. Biol. 20:1436-1447(2000)

PubMed=12077343; DOI=10.1128/mcb.22.14.5157-5172.2002; PMCID=PMC139780
Rheinwald J.G., Hahn W.C., Ramsey M.R., Wu J.Y., Guo Z.-Y., Tsao H., De Luca M., Catricala C., O'Toole K.M.
A two-stage, p16(INK4A)- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status.
Mol. Cell. Biol. 22:5157-5172(2002)

PubMed=19489101; DOI=10.1002/stem.64; PMCID=PMC2733375
Dabelsteen S., Hercule P., Barron P., Rice M., Dorsainville G., Rheinwald J.G.
Epithelial cells derived from human embryonic stem cells display p16INK4A senescence, hypermotility, and differentiation properties shared by many P63+ somatic cell types.
Stem Cells 27:1388-1399(2009)

Cross-references
Encyclopedic resources Wikidata; Q95991822
Entry history
Entry creation25-Feb-2019
Last entry update29-Jun-2023
Version number7