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Cellosaurus N/E6E7 (CVCL_UZ61)

[Text version]
Cell line name N/E6E7
Accession CVCL_UZ61
Resource Identification Initiative To cite this cell line use: N/E6E7 (RRID:CVCL_UZ61)
Comments Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Derived from site: In situ; Skin, epidermis; UBERON=UBERON_0001003.
Cell type: Keratinocyte; CL=CL_0000312.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_UZ57 (N)
Sex of cell Male
Age at sampling <1M
Category Transformed cell line
Web pages Provider; BWH dermatology; -; https://dermatology.bwh.harvard.edu/docs/Cell-Culture-Core-Cell-Lines.pdf
Publications

PubMed=12077343; DOI=10.1128/mcb.22.14.5157-5172.2002; PMCID=PMC139780
Rheinwald J.G., Hahn W.C., Ramsey M.R., Wu J.Y., Guo Z.-Y., Tsao H., De Luca M., Catricala C., O'Toole K.M.
A two-stage, p16(INK4A)- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status.
Mol. Cell. Biol. 22:5157-5172(2002)

PubMed=19489101; DOI=10.1002/stem.64; PMCID=PMC2733375
Dabelsteen S., Hercule P., Barron P., Rice M., Dorsainville G., Rheinwald J.G.
Epithelial cells derived from human embryonic stem cells display p16INK4A senescence, hypermotility, and differentiation properties shared by many P63+ somatic cell types.
Stem Cells 27:1388-1399(2009)

Cross-references
Encyclopedic resources Wikidata; Q95991843
Entry history
Entry creation25-Feb-2019
Last entry update10-Apr-2025
Version number10