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Cellosaurus N/TERT-1 (CVCL_CW92)

[Text version]
Cell line name N/TERT-1
Synonyms N/Tert-1; N/TERT 1; N/TERT1; NTERT-1; NTert-1; NTert1
Accession CVCL_CW92
Resource Identification Initiative To cite this cell line use: N/TERT-1 (RRID:CVCL_CW92)
Comments Karyotypic information: 47,XY,+20 (PubMed=28928444).
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Derived from site: In situ; Skin, epidermis; UBERON=UBERON_0001003.
Cell type: Keratinocyte; CL=CL_0000312.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_UZ57 (N)
Children:
CVCL_C3K0 (N/Tert-1 ADRB2)CVCL_C3K1 (N/Tert-1 AKT1)CVCL_C3K2 (N/Tert-1 AMPH)
CVCL_C3K3 (N/Tert-1 BAP1)CVCL_C3K4 (N/Tert-1 CHAF1B)CVCL_C3K5 (N/Tert-1 CHEK2)
CVCL_C3K6 (N/Tert-1 FOSL1)CVCL_C3K7 (N/Tert-1 GARS)CVCL_C3K8 (N/Tert-1 GLTSCR1)
CVCL_C3K9 (N/Tert-1 GPRC5B)CVCL_C3IV (N/Tert-1 HPV16 E6 Flag-HA)CVCL_C3IW (N/Tert-1 HPV16 E6 Flag-HA 8S9A10T)
CVCL_C3IX (N/Tert-1 HPV16 E6 Flag-HA Delta146-151)CVCL_C3IY (N/Tert-1 HPV16 E6 Flag-HA I128T)CVCL_C3IZ (N/Tert-1 HPV16 E6 HA)
CVCL_C3J1 (N/Tert-1 HPV16 E7)CVCL_C3J2 (N/Tert-1 HPV17a E6)CVCL_C3J3 (N/Tert-1 HPV17a E7)
CVCL_C3J4 (N/Tert-1 HPV18 E6)CVCL_C3J5 (N/Tert-1 HPV18 E7)CVCL_C3J6 (N/Tert-1 HPV20 E6)
CVCL_C3J7 (N/Tert-1 HPV25 E6)CVCL_C3J8 (N/Tert-1 HPV25 E7)CVCL_C3J9 (N/Tert-1 HPV2a E6)
CVCL_C3JB (N/Tert-1 HPV2a E7)CVCL_C3JC (N/Tert-1 HPV31 E7)CVCL_C3JD (N/Tert-1 HPV33 E6)
CVCL_C3JF (N/Tert-1 HPV33 E7)CVCL_C3JG (N/Tert-1 HPV38 E6)CVCL_C3JH (N/Tert-1 HPV38 E7)
CVCL_C3JI (N/Tert-1 HPV45 E6)CVCL_C3JJ (N/Tert-1 HPV45 E7)CVCL_C3JK (N/Tert-1 HPV52 E6)
CVCL_C3JL (N/Tert-1 HPV55 E7)CVCL_C3JM (N/Tert-1 HPV57 E6)CVCL_C3JN (N/Tert-1 HPV57 E7)
CVCL_C3JP (N/Tert-1 HPV6b E6)CVCL_C3JQ (N/Tert-1 HPV6b E7)CVCL_C3JR (N/Tert-1 HPV74 E7)
CVCL_C3JS (N/Tert-1 HPV76 E6)CVCL_C3JT (N/Tert-1 HPV76 E7)CVCL_C3JU (N/Tert-1 HPV8 E6)
CVCL_C3JV (N/Tert-1 HPV8 E7)CVCL_C3JW (N/Tert-1 HPV92 E6)CVCL_C3JX (N/Tert-1 HPV92 E7)
CVCL_C3JY (N/Tert-1 HPV98 E6)CVCL_C3JZ (N/Tert-1 HPV98 E7)CVCL_C3KA (N/Tert-1 JUN)
CVCL_C3KB (N/Tert-1 NIPA1)CVCL_C3KC (N/Tert-1 PP2CA)CVCL_C3KD (N/Tert-1 PTENP1)
CVCL_C3KE (N/Tert-1 PTPN18)CVCL_C3KF (N/Tert-1 PXMP3)CVCL_C3KG (N/Tert-1 RBCK1)
CVCL_C3KH (N/Tert-1 SNCG)CVCL_C3KI (N/Tert-1 SRC)CVCL_C3KJ (N/Tert-1 STAT4)
CVCL_C3KK (N/Tert-1 TBPL1)CVCL_C3KL (N/Tert-1 TCTE1)CVCL_C3KM (N/Tert-1 TIMP1)
CVCL_C3KN (N/Tert-1 UBE3AI)CVCL_C3KP (N/Tert-1 UBOX5)CVCL_C3KQ (N/Tert-1 UCHL3)
CVCL_C3KR (N/Tert-1 UCHL5)CVCL_C3KS (N/Tert-1 USP10)CVCL_C3KT (N/Tert-1 USP12)
CVCL_C3KU (N/Tert-1 USP13)CVCL_C3KV (N/Tert-1 USP21)CVCL_C3KW (N/Tert-1 USP28)
CVCL_C3KX (N/Tert-1 USP39)CVCL_C3KY (N/Tert-1 USP5)CVCL_C3KZ (N/Tert-1 USP52)
CVCL_C3L0 (N/Tert-1 WHSC2)CVCL_C3L1 (N/Tert-1 WWP2)CVCL_C3LA (N/Tert-1 ZER1)
Sex of cell Male
Age at sampling <1M
Category Telomerase immortalized cell line
Web pages https://dermatology.bwh.harvard.edu/docs/Cell-Culture-Core-Cell-Lines.pdf
Publications

PubMed=10648628; DOI=10.1128/mcb.20.4.1436-1447.2000; PMCID=PMC85304
Dickson M.A., Hahn W.C., Ino Y., Ronfard V., Wu J.Y., Weinberg R.A., Louis D.N., Li F.P., Rheinwald J.G.
Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics.
Mol. Cell. Biol. 20:1436-1447(2000)

PubMed=28928444; DOI=10.1038/s41598-017-12041-y; PMCID=PMC5605545
Smits J.P.H., Niehues H., Rikken G., van Vlijmen-Willems I.M.J.J., van de Zande G.W.H.J.F., Zeeuwen P.L.J.M., Schalkwijk J., van den Bogaard E.H.J.
Immortalized N/TERT keratinocytes as an alternative cell source in 3D human epidermal models.
Sci. Rep. 7:11838-11838(2017)

Cross-references
Encyclopedic resources Wikidata; Q54907285
Entry history
Entry creation13-Jul-2016
Last entry update19-Dec-2024
Version number13