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Cellosaurus W12 [Human keratinocyte] (CVCL_T290)

[Text version]
Cell line name W12 [Human keratinocyte]
Accession CVCL_T290
Resource Identification Initiative To cite this cell line use: W12 [Human keratinocyte] (RRID:CVCL_T290)
Comments Virology: At early passages contains about 100 HPV16 episomes per cell (PubMed=7707525).
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Donor information: Established from a patient suffering from a low-grade squamous intraepithelial lesion (LG-SIL) (PubMed=2467886).
Derived from site: In situ; Skin, epidermis; UBERON=UBERON_0001003.
Cell type: Keratinocyte; CL=CL_0000312.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_T291 (S12 [Human keratinocyte])CVCL_D6N8 (W12 clone 20822)CVCL_D6N9 (W12 clone 20850)
CVCL_D6NA (W12 clone 20861)CVCL_D6NB (W12 clone 20862)CVCL_D6N7 (W12 clone 20863)
Sex of cell Female
Age at sampling 22Y
Category Transformed cell line
Publications

PubMed=2467886; DOI=10.1002/ijc.2910430422
Stanley M.A., Browne H.M., Appleby M., Minson A.C.
Properties of a non-tumorigenic human cervical keratinocyte cell line.
Int. J. Cancer 43:672-676(1989)

PubMed=7707525; DOI=10.1128/JVI.69.5.2989-2997.1995; PMCID=PMC188998
Jeon S., Allen-Hoffmann B.L., Lambert P.F.
Integration of human papillomavirus type 16 into the human genome correlates with a selective growth advantage of cells.
J. Virol. 69:2989-2997(1995)

PubMed=16505361; DOI=10.1073/pnas.0600078103; PMCID=PMC1383496
Pett M.R., Herdman M.T., Palmer R.D., Yeo G.S.H., Shivji M.K.K., Stanley M.A., Coleman N.
Selection of cervical keratinocytes containing integrated HPV16 associates with episome loss and an endogenous antiviral response.
Proc. Natl. Acad. Sci. U.S.A. 103:3822-3827(2006)

Cross-references
Encyclopedic resources Wikidata; Q54993456
Entry history
Entry creation03-Feb-2014
Last entry update10-Sep-2024
Version number16