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Cellosaurus W12 clone 20863 (CVCL_D6N7)

[Text version]
Cell line name W12 clone 20863
Synonyms W12E
Accession CVCL_D6N7
Resource Identification Initiative To cite this cell line use: W12 clone 20863 (RRID:CVCL_D6N7)
Comments Virology: Contains about 1000 HPV16 episomes per cell (PubMed=7707525).
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Donor information: Established from a patient suffering from a low-grade squamous intraepithelial lesion (LG-SIL) (from parent cell line).
Derived from site: In situ; Skin, epidermis; UBERON=UBERON_0001003.
Cell type: Keratinocyte; CL=CL_0000312.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_T290 (W12 [Human keratinocyte])
Sex of cell Female
Age at sampling 22Y
Category Transformed cell line
Publications

PubMed=7707525; DOI=10.1128/JVI.69.5.2989-2997.1995; PMCID=PMC188998
Jeon S., Allen-Hoffmann B.L., Lambert P.F.
Integration of human papillomavirus type 16 into the human genome correlates with a selective growth advantage of cells.
J. Virol. 69:2989-2997(1995)

PubMed=29021401; DOI=10.1128/JVI.01001-17; PMCID=PMC5709591
Klymenko T., Gu Q., Herbert I., Stevenson A., Iliev V., Watkins G., Pollock C.S., Bhatia R., Cuschieri K., Herzyk P., Gatherer D., Graham S.V.
RNA-Seq analysis of differentiated keratinocytes reveals a massive response to late events during human papillomavirus 16 infection, including loss of epithelial barrier function.
J. Virol. 91:e01001.17.1-e01001.17.17(2017)

Entry history
Entry creation10-Sep-2024
Last entry update10-Sep-2024
Version number1