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Cellosaurus Ma-Mel-48b (CVCL_N786)

[Text version]
Cell line name Ma-Mel-48b
Accession CVCL_N786
Resource Identification Initiative To cite this cell line use: Ma-Mel-48b (RRID:CVCL_N786)
Comments Omics: SNP array analysis.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations
  • Gene deletion; HGNC; HGNC:914; B2M; Zygosity=Heterozygous (PubMed=25294904).
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Gly469Arg (c.1405G>A); ClinVar=VCV000177775; Zygosity=Unspecified (PubMed=23348503).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (PubMed=23348503).
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_A183 ! Ma-Mel-48a
CVCL_N787 ! Ma-Mel-48c
Sex of cell Male
Age at sampling 88Y
Category Cancer cell line
Publications

PubMed=23348503; DOI=10.1126/science.1230062
Horn S., Figl A., Rachakonda P.S., Fischer C., Sucker A., Gast A., Kadel S., Moll I., Nagore E., Hemminki K., Schadendorf D., Kumar R.
TERT promoter mutations in familial and sporadic melanoma.
Science 339:959-961(2013)

PubMed=25294904; DOI=10.1158/1078-0432.CCR-14-0567; PMCID=PMC8728890
Sucker A., Zhao F., Real B., Heeke C., Bielefeld N., Massen S., Horn S., Moll I., Maltaner R., Horn P.A., Schilling B., Sabbatino F., Lennerz V., Kloor M., Ferrone S., Schadendorf D., Falk C.S., Griewank K.G., Paschen A.
Genetic evolution of T-cell resistance in the course of melanoma progression.
Clin. Cancer Res. 20:6593-6604(2014)

Cross-references
Cell line databases/resources cancercelllines; CVCL_N786
Encyclopedic resources Wikidata; Q54903806
Gene expression databases GEO; GSM1467847
Polymorphism and mutation databases Cosmic; 1846630
Cosmic; 2686418
Cosmic; 2757114
Progenetix; CVCL_N786
Entry history
Entry creation05-Nov-2013
Last entry update19-Dec-2024
Version number12