Cellosaurus cell line Ma-Mel-48c (CVCL

Cellosaurus Ma-Mel-48c (CVCL_N787)

Cross-references
Cell line name	Ma-Mel-48c
Accession	CVCL_N787
Resource Identification Initiative	To cite this cell line use: Ma-Mel-48c (RRID:CVCL_N787)
Comments	Omics: SNP array analysis. Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations	Gene deletion; HGNC; HGNC:914; B2M; Zygosity=Heterozygous (PubMed=25294904). Mutation; HGNC; HGNC:914; B2M; Simple; p.Asp96fs*4; Zygosity=Heterozygous (PubMed=25294904). Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Gly469Arg (c.1405G>A); ClinVar=VCV000177775; Zygosity=Unspecified (PubMed=23348503). Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (PubMed=23348503).
Disease	Melanoma (NCIt: C3224)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual	CVCL_A183 ! Ma-Mel-48a CVCL_N786 ! Ma-Mel-48b
Sex of cell	Male
Age at sampling	88Y
Category	Cancer cell line
Publications	PubMed=23348503; DOI=10.1126/science.1230062 Horn S., Figl A., Rachakonda P.S., Fischer C., Sucker A., Gast A., Kadel S., Moll I., Nagore E., Hemminki K., Schadendorf D., Kumar R. TERT promoter mutations in familial and sporadic melanoma. Science 339:959-961(2013) PubMed=25294904; DOI=10.1158/1078-0432.CCR-14-0567; PMCID=PMC8728890 Sucker A., Zhao F., Real B., Heeke C., Bielefeld N., Massen S., Horn S., Moll I., Maltaner R., Horn P.A., Schilling B., Sabbatino F., Lennerz V., Kloor M., Ferrone S., Schadendorf D., Falk C.S., Griewank K.G., Paschen A. Genetic evolution of T-cell resistance in the course of melanoma progression. Clin. Cancer Res. 20:6593-6604(2014)
Cell line databases/resources	cancercelllines; CVCL_N787
Encyclopedic resources	Wikidata; Q54903807
Gene expression databases	GEO; GSM1467848
Polymorphism and mutation databases	Cosmic; 1846631 Cosmic; 2686419 Cosmic; 2757115 Progenetix; CVCL_N787
Entry history
Entry creation	05-Nov-2013
Last entry update	19-Dec-2024
Version number	12