ID   Ma-Mel-48b
AC   CVCL_N786
DR   cancercelllines; CVCL_N786
DR   Cosmic; 1846630
DR   Cosmic; 2686418
DR   Cosmic; 2757114
DR   GEO; GSM1467847
DR   Progenetix; CVCL_N786
DR   Wikidata; Q54903806
RX   PubMed=23348503;
RX   PubMed=25294904;
CC   Sequence variation: Gene deletion; HGNC; HGNC:914; B2M; Zygosity=Heterozygous (PubMed=25294904).
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Gly469Arg (c.1405G>A); ClinVar=VCV000177775; Zygosity=Unspecified (PubMed=23348503).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (PubMed=23348503).
CC   Omics: SNP array analysis.
CC   Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
DI   NCIt; C3224; Melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_A183 ! Ma-Mel-48a
OI   CVCL_N787 ! Ma-Mel-48c
SX   Male
AG   88Y
CA   Cancer cell line
DT   Created: 05-11-13; Last updated: 19-12-24; Version: 12
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RX   PubMed=23348503; DOI=10.1126/science.1230062;
RA   Horn S., Figl A., Rachakonda P.S., Fischer C., Sucker A., Gast A.,
RA   Kadel S., Moll I., Nagore E., Hemminki K., Schadendorf D., Kumar R.;
RT   "TERT promoter mutations in familial and sporadic melanoma.";
RL   Science 339:959-961(2013).
//
RX   PubMed=25294904; DOI=10.1158/1078-0432.CCR-14-0567; PMCID=PMC8728890;
RA   Sucker A., Zhao F., Real B., Heeke C., Bielefeld N., Massen S.,
RA   Horn S., Moll I., Maltaner R., Horn P.A., Schilling B., Sabbatino F.,
RA   Lennerz V., Kloor M., Ferrone S., Schadendorf D., Falk C.S.,
RA   Griewank K.G., Paschen A.;
RT   "Genetic evolution of T-cell resistance in the course of melanoma
RT   progression.";
RL   Clin. Cancer Res. 20:6593-6604(2014).
//