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Cellosaurus HB1.F3.Ras (CVCL_LJ48)

[Text version]
Cell line name HB1.F3.Ras
Synonyms F3.Ras
Accession CVCL_LJ48
Resource Identification Initiative To cite this cell line use: HB1.F3.Ras (RRID:CVCL_LJ48)
Comments Characteristics: Tumorigenic, forms brain cancers when injected in mouse brains.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:5173; HRAS (Note=With p.Gly12Val).
Genetic integration: Method=Transduction; Gene=UniProtKB; P01110; Avian myelocytomatosis virus MC29 v-Myc.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
Transformant: v-Myc.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Fetal brain, telencephalon; UBERON=UBERON_0014371.
Cell type: Neural stem cell; CL=CL_0000047.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_LJ44 (HB1.F3)
Sex of cell Female
Age at sampling 14FW
Category Transformed cell line
Publications

PubMed=21755312; DOI=10.1007/s12015-011-9280-4; PMCID=PMC4043123
Lee J.-S., Lee H.J., Moon B.-H., Song S.-H., Lee M.-O., Shim S.H., Kim H.S., Lee M.C., Kwon J.T., Fornace A.J. Jr., Kim S.U., Cha H.-J.
Generation of cancerous neural stem cells forming glial tumor by oncogenic stimulation.
Stem Cell Rev. Rep. 8:532-545(2012)

PubMed=25096191; DOI=10.1093/neuonc/nou145; PMCID=PMC4483050
Lee J.-S., Park J.-R., Kwon O.-S., Lee T.-H., Nakano I., Miyoshi H., Chun K.-H., Park M.-J., Lee H.J., Kim S.U., Cha H.-J.
SIRT1 is required for oncogenic transformation of neural stem cells and for the survival of 'cancer cells with neural stemness' in a p53-dependent manner.
Neuro-oncol. 17:95-106(2015)

Cross-references
Encyclopedic resources Wikidata; Q54881356
Entry history
Entry creation15-Nov-2017
Last entry update19-Dec-2024
Version number9