ID   HB1.F3.Ras
AC   CVCL_LJ48
SY   F3.Ras
DR   Wikidata; Q54881356
RX   PubMed=21755312;
RX   PubMed=25096191;
CC   Characteristics: Tumorigenic, forms brain cancers when injected in mouse brains.
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:5173; HRAS (Note=With p.Gly12Val).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P01110; Avian myelocytomatosis virus 29 v-Myc.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
CC   Transformant: v-Myc.
CC   Omics: Transcriptomics; Microarray.
CC   Derived from site: In situ; Fetal brain, telencephalon; UBERON=UBERON_0014371.
CC   Cell type: Neural stem cell; CL=CL_0000047.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_LJ44 ! HB1.F3
SX   Female
AG   14FW
CA   Transformed cell line
DT   Created: 15-11-17; Last updated: 14-08-25; Version: 11
//
RX   PubMed=21755312; DOI=10.1007/s12015-011-9280-4; PMCID=PMC4043123;
RA   Lee, Ji-Seon
RA   Lee, Hong Jun
RA   Moon, Bo-Hyun
RA   Song, Seung-Hyun
RA   Lee, Mi-Ok
RA   Shim, Sung Han
RA   Kim, Hyung Seok
RA   Lee, Min Cheol
RA   Kwon, Jeong Taik
RA   Fornace, Albert J. Jr.
RA   Kim, Seung U.
RA   Cha, Hyuk-Jin
RT   "Generation of cancerous neural stem cells forming glial tumor by
RT   oncogenic stimulation.";
RL   Stem Cell Rev. Rep. 8:532-545(2012).
//
RX   PubMed=25096191; DOI=10.1093/neuonc/nou145; PMCID=PMC4483050;
RA   Lee, Ji-Seon
RA   Park, Jeong-Rak
RA   Kwon, Ok-Seon
RA   Lee, Tae-Hee
RA   Nakano, Ichiro
RA   Miyoshi, Hiroyuki
RA   Chun, Kwang-Hoon
RA   Park, Myung-Jin
RA   Lee, Hong Jun
RA   Kim, Seung U.
RA   Cha, Hyuk-Jin
RT   "SIRT1 is required for oncogenic transformation of neural stem cells
RT   and for the survival of 'cancer cells with neural stemness' in a
RT   p53-dependent manner.";
RL   Neuro-oncol. 17:95-106(2015).
//