ID   HB1.F3.Ras
AC   CVCL_LJ48
SY   F3.Ras
DR   Wikidata; Q54881356
RX   PubMed=21755312;
RX   PubMed=25096191;
CC   Characteristics: Tumorigenic, forms brain cancers when injected in mouse brains.
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:5173; HRAS (Note=With p.Gly12Val).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P01110; Avian myelocytomatosis virus MC29 v-Myc.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
CC   Transformant: v-Myc.
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: In situ; Fetal brain, telencephalon; UBERON=UBERON_0014371.
CC   Cell type: Neural stem cell; CL=CL_0000047.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_LJ44 ! HB1.F3
SX   Female
AG   14FW
CA   Transformed cell line
DT   Created: 15-11-17; Last updated: 19-12-24; Version: 9
//
RX   PubMed=21755312; DOI=10.1007/s12015-011-9280-4; PMCID=PMC4043123;
RA   Lee J.-S., Lee H.J., Moon B.-H., Song S.-H., Lee M.-O., Shim S.H.,
RA   Kim H.S., Lee M.C., Kwon J.T., Fornace A.J. Jr., Kim S.U.,
RA   Cha H.-J.;
RT   "Generation of cancerous neural stem cells forming glial tumor by
RT   oncogenic stimulation.";
RL   Stem Cell Rev. Rep. 8:532-545(2012).
//
RX   PubMed=25096191; DOI=10.1093/neuonc/nou145; PMCID=PMC4483050;
RA   Lee J.-S., Park J.-R., Kwon O.-S., Lee T.-H., Nakano I., Miyoshi H.,
RA   Chun K.-H., Park M.-J., Lee H.J., Kim S.U., Cha H.-J.;
RT   "SIRT1 is required for oncogenic transformation of neural stem cells
RT   and for the survival of 'cancer cells with neural stemness' in a
RT   p53-dependent manner.";
RL   Neuro-oncol. 17:95-106(2015).
//