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Cellosaurus HB1.F3.EGFRviii (CVCL_LJ46)

[Text version]
Cell line name HB1.F3.EGFRviii
Synonyms F3.EGFRviii
Accession CVCL_LJ46
Resource Identification Initiative To cite this cell line use: HB1.F3.EGFRviii (RRID:CVCL_LJ46)
Comments Characteristics: EGFRviii expression is doxycycline inducible (PubMed=28830458).
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:3236; EGFR (Note=With p.Val30_Arg297del = EGFRvIII).
Genetic integration: Method=Transduction; Gene=UniProtKB; P01110; Avian myelocytomatosis virus MC29 v-Myc.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Transformant: v-Myc.
Derived from site: In situ; Fetal brain, telencephalon; UBERON=UBERON_0014371.
Cell type: Neural stem cell; CL=CL_0000047.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_LJ44 (HB1.F3)
Sex of cell Female
Age at sampling 14FW
Category Transformed cell line
Publications

PubMed=28830458; DOI=10.1186/s12943-017-0703-y; PMCID=PMC5567886
Kwon S.-J., Kwon O.-S., Kim K.-T., Go Y.-H., Yu S.-I., Lee B.-H., Miyoshi H., Oh E., Cho S.-J., Cha H.-J.
Role of MEK partner-1 in cancer stemness through MEK/ERK pathway in cancerous neural stem cells, expressing EGFRviii.
Mol. Cancer 16:140.1-140.13(2017)

Cross-references
Encyclopedic resources Wikidata; Q54881354
Entry history
Entry creation15-Nov-2017
Last entry update19-Dec-2024
Version number9