Cellosaurus cell line CFBE41o- (CVCL

Cellosaurus CFBE41o- (CVCL_HL93)

[Text version]

Cell line name

CFBE41o-

Synonyms

CFBE41o(-); CF41o; CFBE

Accession

CVCL_HL93

Resource Identification Initiative

To cite this cell line use: CFBE41o- (RRID:CVCL_HL93)

Comments

Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=pSVori-).
Omics: Proteome analysis by 2D-DE/MS.
Derived from site: In situ; Lung, bronchus, epithelium; UBERON=UBERON_0002031.
Cell type: Epithelial cell of bronchus; CL=CL_0002328.

Sequence variations

Mutation; HGNC; HGNC:1884; CFTR; Simple; p.Phe508del (c.1521_1523delCTT); ClinVar=VCV000007105; Zygosity=Homozygous (PubMed=15463957).

Disease

Cystic fibrosis (NCIt: C2975)
Cystic fibrosis (ORDO: Orphanet_586)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Children:

CVCL_WZ18 (CF8Flp)	CVCL_VP35 (CFBE41o- 4.7 DeltaF508-CFTR)	CVCL_VP34 (CFBE41o- 4.7 WT-CFTR)
CVCL_VP37 (CFBE41o- 6.2 DeltaF508-CFTR)	CVCL_VP36 (CFBE41o- 6.2 WT-CFTR)

Sex of cell

Sex unspecified

Age at sampling

Age unspecified

Category

Transformed cell line

STR profile

Source(s): Millipore=SCC151

Markers:

Amelogenin	X
CSF1PO	11
D3S1358	16,18
D5S818	13
D7S820	8,11
D8S1179	11,14
D13S317	9,11
D16S539	12
D18S51	15,16
D21S11	29,31.2
FGA	22,24
Penta D	11,12
Penta E	12
TH01	9.3
TPOX	8,9
vWA	17

Web pages

https://web.archive.org/web/20190126194809/http://www.dartmouth.edu/~cysfib/cell-lines.html

Publications

PubMed=9614386; DOI=10.1002/(SICI)1096-9896(199803)184:3<323::AID-PATH2>3.0.CO;2-2
Meng Q.-H., Springall D.R., Bishop A.E., Morgan K., Evans T.J., Habib S., Gruenert D.C., Gyi K.M., Hodson M.E., Yacoub M.H., Polak J.M.
Lack of inducible nitric oxide synthase in bronchial epithelium: a possible mechanism of susceptibility to infection in cystic fibrosis.
J. Pathol. 184:323-331(1998)

PubMed=12032687; DOI=10.1038/sj.gt.3301741
Bruscia E.M., Sangiuolo F., Sinibaldi P., Goncz K.K., Novelli G., Gruenert D.C.
Isolation of CF cell lines corrected at DeltaF508-CFTR locus by SFHR-mediated targeting.
Gene Ther. 9:683-685(2002)

PubMed=15463957; DOI=10.1016/j.jcf.2004.05.040
Gruenert D.C., Willems M., Cassiman J.-J., Frizzell R.A.
Established cell lines used in cystic fibrosis research.
J. Cyst. Fibros. 3:191-196(2004)

PubMed=16249874; DOI=10.1007/s00441-005-0062-7
Ehrhardt C., Collnot E.-M., Baldes C., Becker U., Laue M., Kim K.-J., Lehr C.-M.
Towards an in vitro model of cystic fibrosis small airway epithelium: characterisation of the human bronchial epithelial cell line CFBE41o-.
Cell Tissue Res. 323:405-415(2006)

PubMed=28970102; DOI=10.1016/j.jprot.2017.09.013
Puglia M., Landi C., Gagliardi A., Breslin L., Armini A., Brunetti J., Pini A., Bianchi L., Bini L.
The proteome speciation of an immortalized cystic fibrosis cell line: new perspectives on the pathophysiology of the disease.
J. Proteomics 170:28-42(2018)

Cross-references

Cell line collections (Providers)

Millipore; SCC151

Cell line databases/resources

Lonza; 1158

Encyclopedic resources

Wikidata; Q54811428

Experimental variables resources

EFO; EFO_0022620

Gene expression databases

GEO; GSM2126999
GEO; GSM2127001
GEO; GSM2127003

Proteomic databases