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Cellosaurus CFBE41o- 4.7 WT-CFTR (CVCL_VP34)

[Text version]
Cell line name CFBE41o- 4.7 WT-CFTR
Accession CVCL_VP34
Resource Identification Initiative To cite this cell line use: CFBE41o- 4.7 WT-CFTR (RRID:CVCL_VP34)
Comments Genetic integration: Method=Transfection; Gene=HGNC; HGNC:1884; CFTR.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=pSVori-).
Caution: While not directly described in PubMed=18769032, that paper describes the process and constructs used to derive this cell line.
Derived from site: In situ; Lung, bronchus, epithelium; UBERON=UBERON_0002031.
Cell type: Epithelial cell of bronchus; CL=CL_0002328.
Sequence variations
  • Mutation; HGNC; HGNC:1884; CFTR; Simple; p.Phe508del (c.1521_1523delCTT); ClinVar=VCV000007105; Zygosity=Unspecified; Note=In the 2 genomic alleles while the transfected copies are wildtype (PubMed=18769032).
Disease Cystic fibrosis (NCIt: C2975)
Cystic fibrosis (ORDO: Orphanet_586)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_HL93 (CFBE41o-)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Transformed cell line
STR profile Source(s): Millipore=SCC158

Markers:
AmelogeninX
CSF1PO11
D3S135816,18
D5S81811,13
D7S8208,11
D8S117911,14
D13S3179,11
D16S53912
D18S5115,16
D21S1131.2
FGA22,24
Penta D12
Penta E12
TH019.3
TPOX8,9
vWA17

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Publications

PubMed=18769032; DOI=10.1159/000149783; PMCID=PMC2927120
Illek B., Maurisse R., Wahler L., Kunzelmann K., Fischer H., Gruenert D.C.
Cl transport in complemented CF bronchial epithelial cells correlates with CFTR mRNA expression levels.
Cell. Physiol. Biochem. 22:57-68(2008)

Cross-references
Cell line collections (Providers) Millipore; SCC158
Encyclopedic resources Wikidata; Q93447382
Entry history
Entry creation07-Sep-2018
Last entry update19-Dec-2024
Version number14