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Cellosaurus U2OS-FGFR1 (CVCL_E6ZY)

[Text version]
Cell line name U2OS-FGFR1
Synonyms U2OS FGFR1; U2OS-R1
Accession CVCL_E6ZY
Resource Identification Initiative To cite this cell line use: U2OS-FGFR1 (RRID:CVCL_E6ZY)
Comments Population: Caucasian.
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:3688; FGFR1.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Derived from site: In situ; Bone, tibia; UBERON=UBERON_0000979.
Sequence variations
  • Mutation; HGNC; HGNC:9277; PPM1D; Simple; p.Arg458Ter (c.1372C>T); ClinVar=VCV002445214; Zygosity=Heterozygous (from parent cell line).
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0042 (U2OS)
Sex of cell Female
Age at sampling 15Y
Category Cancer cell line
Web pages Provider; I2B; P-95; http://inven2biologics.com/shop/cell-lines/human/u2os-fgfr1-osteosarcoma-cell-line
Publications

PubMed=18480409; DOI=10.1091/mbc.e07-12-1219; PMCID=PMC2488279
Haugsten E.M., Malecki J.M., Stordal Bjorklund S.M., Olsnes S., Wesche J.
Ubiquitination of fibroblast growth factor receptor 1 is required for its intracellular sorting but not for its endocytosis.
Mol. Biol. Cell 19:3390-3403(2008)

PubMed=21779335; DOI=10.1371/journal.pone.0021708; PMCID=PMC3136467
Haugsten E.M., Zakrzewska M., Brech A., Pust S., Olsnes S., Sandvig K., Wesche J.
Clathrin- and dynamin-independent endocytosis of FGFR3 -- implications for signalling.
PLoS ONE 6:e21708.1-e21708.13(2011)

Entry history
Entry creation10-Apr-2025
Last entry update10-Apr-2025
Version number1