ID   U2OS-FGFR1
AC   CVCL_E6ZY
SY   U2OS FGFR1; U2OS-R1
RX   PubMed=18480409;
RX   PubMed=21779335;
WW   Provider; I2B; P-95; http://inven2biologics.com/shop/cell-lines/human/u2os-fgfr1-osteosarcoma-cell-line
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; HGNC:9277; PPM1D; Simple; p.Arg458Ter (c.1372C>T); ClinVar=VCV002445214; Zygosity=Heterozygous (from parent cell line).
CC   Genetic integration: Method=Transfection; Gene=HGNC; HGNC:3688; FGFR1.
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Derived from site: In situ; Bone, tibia; UBERON=UBERON_0000979.
DI   NCIt; C9145; Osteosarcoma
DI   ORDO; Orphanet_668; Osteosarcoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0042 ! U2OS
SX   Female
AG   15Y
CA   Cancer cell line
DT   Created: 10-04-25; Last updated: 10-04-25; Version: 1
//
RX   PubMed=18480409; DOI=10.1091/mbc.e07-12-1219; PMCID=PMC2488279;
RA   Haugsten E.M., Malecki J.M., Stordal Bjorklund S.M., Olsnes S.,
RA   Wesche J.;
RT   "Ubiquitination of fibroblast growth factor receptor 1 is required for
RT   its intracellular sorting but not for its endocytosis.";
RL   Mol. Biol. Cell 19:3390-3403(2008).
//
RX   PubMed=21779335; DOI=10.1371/journal.pone.0021708; PMCID=PMC3136467;
RA   Haugsten E.M., Zakrzewska M., Brech A., Pust S., Olsnes S., Sandvig K.,
RA   Wesche J.;
RT   "Clathrin- and dynamin-independent endocytosis of FGFR3 -- implications
RT   for signalling.";
RL   PLoS ONE 6:e21708.1-e21708.13(2011).
//