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Cellosaurus EYQ2-20 (CVCL_E4CE)

[Text version]
Cell line name EYQ2-20
Accession CVCL_E4CE
Resource Identification Initiative To cite this cell line use: EYQ2-20 (RRID:CVCL_E4CE)
Comments Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:14294; SHANK3 (Note=1 of 2 alleles).
Derived from site: In situ; Blastocyst; UBERON=UBERON_0000358.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_9773 (WA09)
Sex of cell Female
Age at sampling Blastocyst stage
Category Embryonic stem cell
Publications

PubMed=33558651; DOI=10.1038/s41380-021-01023-2; PMCID=PMC8349370
Chiola S., Napan K.L., Wang Y.-Q., Lazarenko R.M., Armstrong C.J., Cui J., Shcheglovitov A.
Defective AMPA-mediated synaptic transmission and morphology in human neurons with hemizygous SHANK3 deletion engrafted in mouse prefrontal cortex.
Mol. Psychiatry 26:4670-4686(2021)

PubMed=36202854; DOI=10.1038/s41467-022-33364-z; PMCID=PMC9537523
Wang Y.-Q., Chiola S., Yang G., Russell C., Armstrong C.J., Wu Y.-Y., Spampanato J.G., Tarboton P., Ullah H.M.A., Edgar N.U., Chang A.N., Harmin D.A., Bocchi V.D., Vezzoli E., Besusso D., Cui J., Cattaneo E., Kubanek J., Shcheglovitov A.
Modeling human telencephalic development and autism-associated SHANK3 deficiency using organoids generated from single neural rosettes.
Nat. Commun. 13:5688.1-5688.25(2022)

Entry history
Entry creation19-Dec-2024
Last entry update19-Dec-2024
Version number1