| Cell line name |
12D7-NEO |
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| Accession |
CVCL_E3GC |
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| Resource Identification Initiative |
To cite this cell line use: 12D7-NEO (RRID:CVCL_E3GC) |
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| Comments |
Population: Caucasian.
Characteristics: Control cell line for 12D7-MDR1 (Cellosaurus=CVCL_A9MA), 12D7-MDR1-IRES-DHFR (Cellosaurus=CVCL_E3GD) and 12D7-MDR1mt-IRES-DHFR (Cellosaurus=CVCL_E3GE) (PubMed=10698967).
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178. |
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| Sequence variations |
- Gene fusion; HGNC; HGNC:13222; BCL11B + HGNC; HGNC:2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
- Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
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| Disease |
Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_W647 (12D7) |
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| Sex of cell |
Female |
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| Age at sampling |
3Y11M |
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| Category |
Cancer cell line |
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| Publications | PubMed=10698967; DOI=10.1096/fasebj.14.3.516
Lee C.G.L., Ramachandra M., Jeang K.-T., Martin M.A., Pastan I., Gottesman M.M.
Effect of ABC transporters on HIV-1 infection: inhibition of virus production by the MDR1 transporter.
FASEB J. 14:516-522(2000) |
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| Entry history |
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| Entry creation | 19-Dec-2024 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 1 |
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