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Cellosaurus 12D7-MDR1mt-IRES-DHFR (CVCL_E3GE)

[Text version]
Cell line name 12D7-MDR1mt-IRES-DHFR
Synonyms 12D7-pHMIDmt
Accession CVCL_E3GE
Resource Identification Initiative To cite this cell line use: 12D7-MDR1mt-IRES-DHFR (RRID:CVCL_E3GE)
Comments Population: Caucasian.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:40; ABCB1 (Note=With p.Asp555Asn).
Genetic integration: Method=Transduction; Gene=MGI; MGI:94890; Dhfr.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; HGNC:13222; BCL11B + HGNC; HGNC:2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
  • Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_W647 (12D7)
Sex of cell Female
Age at sampling 3Y11M
Category Cancer cell line
Publications

PubMed=10698967; DOI=10.1096/fasebj.14.3.516
Lee C.G.L., Ramachandra M., Jeang K.-T., Martin M.A., Pastan I., Gottesman M.M.
Effect of ABC transporters on HIV-1 infection: inhibition of virus production by the MDR1 transporter.
FASEB J. 14:516-522(2000)

Entry history
Entry creation19-Dec-2024
Last entry update19-Dec-2024
Version number1