| Cell line name |
12D7-MDR1 |
|---|
| Accession |
CVCL_A9MA |
|---|
| Resource Identification Initiative |
To cite this cell line use: 12D7-MDR1 (RRID:CVCL_A9MA) |
|---|
| Comments |
Population: Caucasian.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:40; ABCB1.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178. |
|---|
| Sequence variations |
- Gene fusion; HGNC; HGNC:13222; BCL11B + HGNC; HGNC:2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
- Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
|
|---|
| Disease |
Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861) |
|---|
| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
|---|
| Hierarchy |
Parent: CVCL_W647 (12D7) |
|---|
| Sex of cell |
Female |
|---|
| Age at sampling |
3Y11M |
|---|
| Category |
Cancer cell line |
|---|
| Publications | PubMed=10698967; DOI=10.1096/fasebj.14.3.516
Lee C.G.L., Ramachandra M., Jeang K.-T., Martin M.A., Pastan I., Gottesman M.M.
Effect of ABC transporters on HIV-1 infection: inhibition of virus production by the MDR1 transporter.
FASEB J. 14:516-522(2000) |
|---|
| Cross-references |
|---|
| Cell line databases/resources |
cancercelllines; CVCL_A9MA
|
|---|
| Encyclopedic resources |
Wikidata; Q108819387
|
|---|
| Entry history |
|---|
| Entry creation | 23-Sep-2021 |
|---|
| Last entry update | 19-Dec-2024 |
|---|
| Version number | 8 |
|---|
