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Cellosaurus NHA E6/E7/hTERT/Ras/Akt (CVCL_E3G5)

[Text version]
Cell line name NHA E6/E7/hTERT/Ras/Akt
Accession CVCL_E3G5
Resource Identification Initiative To cite this cell line use: NHA E6/E7/hTERT/Ras/Akt (RRID:CVCL_E3G5)
Comments Genetic integration: Method=Transduction; Gene=HGNC; HGNC:5173; HRAS (Note=With p.Gly12Val).
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transduction; Gene=MGI; MGI:87986; Akt1 (Note=With SRC myristoylation signal MGSSKSKPKDPSQR added at the N-terminus and p.Ala5_Gly130del).
Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Derived from site: In situ; Brain; UBERON=UBERON_0000955.
Cell type: Astrocyte; CL=CL_0000127.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_E3G4 (NHA E6/E7/hTERT/Ras)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Transformed cell line
Publications

PubMed=11559533
Sonoda Y., Ozawa T., Aldape K.D., Deen D.F., Berger M.S., Pieper R.O.
Akt pathway activation converts anaplastic astrocytoma to glioblastoma multiforme in a human astrocyte model of glioma.
Cancer Res. 61:6674-6678(2001)

Entry history
Entry creation19-Dec-2024
Last entry update19-Dec-2024
Version number1