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Cellosaurus NHA E6/E7/hTERT/Ras (CVCL_E3G4)

[Text version]
Cell line name NHA E6/E7/hTERT/Ras
Accession CVCL_E3G4
Resource Identification Initiative To cite this cell line use: NHA E6/E7/hTERT/Ras (RRID:CVCL_E3G4)
Comments Genetic integration: Method=Transduction; Gene=HGNC; HGNC:5173; HRAS (Note=With p.Gly12Val).
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Derived from site: In situ; Brain; UBERON=UBERON_0000955.
Cell type: Astrocyte; CL=CL_0000127.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_E3G5 (NHA E6/E7/hTERT/Ras/Akt)CVCL_Z595 (SK-astrocyte-IDH1)CVCL_Z596 (SK-astrocyte-IDH1-R132H)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Transformed cell line
Publications

PubMed=11431323
Sonoda Y., Ozawa T., Hirose Y., Aldape K.D., McMahon M., Berger M.S., Pieper R.O.
Formation of intracranial tumors by genetically modified human astrocytes defines four pathways critical in the development of human anaplastic astrocytoma.
Cancer Res. 61:4956-4960(2001)

PubMed=11559533
Sonoda Y., Ozawa T., Aldape K.D., Deen D.F., Berger M.S., Pieper R.O.
Akt pathway activation converts anaplastic astrocytoma to glioblastoma multiforme in a human astrocyte model of glioma.
Cancer Res. 61:6674-6678(2001)

Entry history
Entry creation19-Dec-2024
Last entry update19-Dec-2024
Version number1