ID   NHA E6/E7/hTERT/Ras/Akt
AC   CVCL_E3G5
RX   PubMed=11559533;
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:5173; HRAS (Note=With p.Gly12Val).
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
CC   Genetic integration: Method=Transduction; Gene=MGI; MGI:87986; Akt1 (Note=With SRC myristoylation signal MGSSKSKPKDPSQR added at the N-terminus and p.Ala5_Gly130del).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
CC   Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
CC   Derived from site: In situ; Brain; UBERON=UBERON_0000955.
CC   Cell type: Astrocyte; CL=CL_0000127.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_E3G4 ! NHA E6/E7/hTERT/Ras
SX   Sex unspecified
AG   Age unspecified
CA   Transformed cell line
DT   Created: 19-12-24; Last updated: 19-12-24; Version: 1
//
RX   PubMed=11559533;
RA   Sonoda Y., Ozawa T., Aldape K.D., Deen D.F., Berger M.S., Pieper R.O.;
RT   "Akt pathway activation converts anaplastic astrocytoma to
RT   glioblastoma multiforme in a human astrocyte model of glioma.";
RL   Cancer Res. 61:6674-6678(2001).
//