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Cellosaurus SK-astrocyte-IDH1-R132H (CVCL_Z596)

[Text version]
Cell line name SK-astrocyte-IDH1-R132H
Accession CVCL_Z596
Resource Identification Initiative To cite this cell line use: SK-astrocyte-IDH1-R132H (RRID:CVCL_Z596)
Comments From: Memorial Sloan Kettering Cancer Center; New York; USA.
Registration: Memorial Sloan Kettering Cancer Center Office of Technology Development; SK2012-113.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:5173; HRAS (Note=With p.Gly12Val).
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:5382; IDH1 (Note=With p.Arg132His).
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Derived from site: In situ; Brain; UBERON=UBERON_0000955.
Cell type: Astrocyte; CL=CL_0000127.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_E3G4 (NHA E6/E7/hTERT/Ras)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Telomerase immortalized cell line
Publications

PubMed=22343889; DOI=10.1038/nature10866; PMCID=PMC3351699
Turcan S., Rohle D., Goenka A., Walsh L.A., Fang F., Yilmaz E., Campos C., Fabius A.W.M., Lu C., Ward P.S., Thompson C.B., Kaufman A., Guryanova O., Levine R., Heguy A., Viale A.J., Morris L.G.T., Huse J.T., Mellinghoff I.K., Chan T.A.
IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype.
Nature 483:479-483(2012)

Cross-references
Encyclopedic resources Wikidata; Q54953610
Entry history
Entry creation10-Apr-2015
Last entry update19-Dec-2024
Version number12