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Cellosaurus CHO TSHR-289 (CVCL_E3EN)

[Text version]
Cell line name CHO TSHR-289
Synonyms TSHR-289
Accession CVCL_E3EN
Resource Identification Initiative To cite this cell line use: CHO TSHR-289 (RRID:CVCL_E3EN)
Comments Selected for resistance to: ChEBI; CHEBI_44185; Methotrexate (MTX).
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:12373; TSHR (Note=With p.Lys290-Leu764 del).
Genetic integration: Method=Transfection; Gene=MGI; MGI:94890; Dhfr.
Transformant: NCIt; C129640; Cobalt-60 gamma radiation.
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Cell type: Epithelial cell of ovary; CL=CL_2000064.
Sequence variations
  • Gene deletion; UniProtKB; Q2MH30; Dhfr; Zygosity=Homozygous (from parent cell line).
Species of origin Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 10029)
Hierarchy Parent: CVCL_7180 (CHO-DG44)
Sex of cell Female
Age at sampling Adult
Category Transformed cell line
Publications

PubMed=10022441; DOI=10.1210/jcem.84.2.5481
Chazenbalk G.D., Wang Y., Guo J., Hutchison J.S., Segal D., Jaume J.C., McLachlan S.M., Rapoport B.
A mouse monoclonal antibody to a thyrotropin receptor ectodomain variant provides insight into the exquisite antigenic conformational requirement, epitopes and in vivo concentration of human autoantibodies.
J. Clin. Endocrinol. Metab. 84:702-710(1999)

Entry history
Entry creation19-Dec-2024
Last entry update19-Dec-2024
Version number1