ID   CHO TSHR-289
AC   CVCL_E3EN
SY   TSHR-289
RX   PubMed=10022441;
CC   Selected for resistance to: ChEBI; CHEBI_44185; Methotrexate (MTX).
CC   Sequence variation: Gene deletion; UniProtKB; Q2MH30; Dhfr; Zygosity=Homozygous (from parent cell line).
CC   Genetic integration: Method=Transfection; Gene=HGNC; HGNC:12373; TSHR (Note=With p.Lys290-Leu764 del).
CC   Genetic integration: Method=Transfection; Gene=MGI; MGI:94890; Dhfr.
CC   Transformant: NCIt; C129640; Cobalt-60 gamma radiation.
CC   Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
CC   Cell type: Epithelial cell of ovary; CL=CL_2000064.
OX   NCBI_TaxID=10029; ! Cricetulus griseus (Chinese hamster)
HI   CVCL_7180 ! CHO-DG44
SX   Female
AG   Adult
CA   Transformed cell line
DT   Created: 19-12-24; Last updated: 19-12-24; Version: 1
//
RX   PubMed=10022441; DOI=10.1210/jcem.84.2.5481;
RA   Chazenbalk G.D., Wang Y., Guo J., Hutchison J.S., Segal D., Jaume J.C.,
RA   McLachlan S.M., Rapoport B.;
RT   "A mouse monoclonal antibody to a thyrotropin receptor ectodomain
RT   variant provides insight into the exquisite antigenic conformational
RT   requirement, epitopes and in vivo concentration of human
RT   autoantibodies.";
RL   J. Clin. Endocrinol. Metab. 84:702-710(1999).
//