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Cellosaurus CHO-TPO-M1-K1 (CVCL_E3EG)

[Text version]
Cell line name CHO-TPO-M1-K1
Accession CVCL_E3EG
Resource Identification Initiative To cite this cell line use: CHO-TPO-M1-K1 (RRID:CVCL_E3EG)
Comments Selected for resistance to: ChEBI; CHEBI_44185; Methotrexate (MTX).
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:12015; TPO (Note=With p.Trp849_Leu933del, secreted = TPO-M1).
Genetic integration: Method=Transfection; Gene=MGI; MGI:94890; Dhfr.
Transformant: NCIt; C129640; Cobalt-60 gamma radiation.
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Cell type: Epithelial cell of ovary; CL=CL_2000064.
Sequence variations
  • Gene deletion; UniProtKB; Q2MH30; Dhfr; Zygosity=Homozygous (from parent cell line).
Species of origin Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 10029)
Hierarchy Parent: CVCL_7180 (CHO-DG44)
Sex of cell Female
Age at sampling Adult
Category Transformed cell line
Publications

PubMed=2274058; DOI=10.1210/mend-4-5-786
Foti D.P., Kaufman K.D., Chazenbalk G.D., Rapoport B.
Generation of a biologically active, secreted form of human thyroid peroxidase by site-directed mutagenesis.
Mol. Endocrinol. 4:786-791(1990)

PubMed=1936519; DOI=10.1016/0303-7207(91)90191-t
Kaufman K.D., Foti D.P., Seto P., Rapoport B.
Overexpression of an immunologically-intact, secreted form of human thyroid peroxidase in eukaryotic cells.
Mol. Cell. Endocrinol. 78:107-114(1991)

Entry history
Entry creation19-Dec-2024
Last entry update19-Dec-2024
Version number1