Cellosaurus cell line T-REx-293 (CVCL

Cellosaurus T-REx-293 (CVCL_D585)

[Text version]

Cell line name

T-REx-293

Synonyms

T-REx 293; T-REx293; TRex-293; TREx293; T-REx-HEK293; T-REx HEK 293; HEK293-T-REx; HEK293-Trex

Accession

CVCL_D585

Resource Identification Initiative

To cite this cell line use: T-REx-293 (RRID:CVCL_D585)

Comments

Group: Vaccine production cell line.
Part of: ENCODE project common cell types; tier 3.
Biotechnology: Used for the production of the AstraZeneca SARS-CoV-2 (COVID-19) vaccine (Trade name: Vaxzevria; also known as ChAdOx1-SARS-COV-2 or AZD1222) (DrugBank=DB15656). In the context of the vaccine production, the tetR repressor blocks the expression of the SARS-CoV-2 spike protein gene during production of the recombinant adenoviral vector, thereby optimising vector production.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P04483; Escherichia coli Tn10 tetR.
Transformant: NCBI_TaxID; 28285; Adenovirus 5.
Derived from site: In situ; Fetal kidney; UBERON=UBERON_0002113.

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Parent: CVCL_0045 (HEK293)
Children:

CVCL_U427 (Flp-In-T-REx-293)	CVCL_C3MN (HEK293 H5M2)	CVCL_E3BV (HEK293 TC4-2A)
CVCL_E3BX (HEK293 TC4-2B)	CVCL_E3BZ (HEK293 TC4-3)	CVCL_E3BW (HEK293 TL4-2A)
CVCL_E3BY (HEK293 TL4-2B)	CVCL_E3C0 (HEK293 TL4-3)	CVCL_YL74 (Jump-In T-REx HEK 293)
CVCL_C9E4 (SB Drug Discovery Inducible HEK-GluN1/2A)

Sex of cell

Female

Age at sampling

Fetus