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Cellosaurus D492M (CVCL_D1HK)

[Text version]
Cell line name D492M
Synonyms D492 Mesenchymal
Accession CVCL_D1HK
Resource Identification Initiative To cite this cell line use: D492M (RRID:CVCL_D1HK)
Comments Characteristics: Has a mesenchymal phenotype, measured by a spindle like phenotype in culture and by marker expression. Has lost epithelial markers such as keratins, CDH1 and transcription factors such as TP63. Has gained mesenchymal marker expression including CDH2, VIM and alpha smooth muscle actin (PubMed=21915264; PubMed=30684066).
Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Breast, epithelium; UBERON=UBERON_0008367.
Cell type: Luminal epithelial cell; CL=CL_0002326.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_D1HJ (D492)
Sex of cell Female
Age at sampling Adult
Category Transformed cell line
Publications

PubMed=21915264; DOI=10.1371/journal.pone.0023833; PMCID=PMC3167828
Sigurdsson V., Hilmarsdottir B., Sigmundsdottir H., Fridriksdottir A.J.R., Ringner M., Villadsen R., Borg A., Agnarsson B.A., Petersen O.W., Magnusson M.K., Gudjonsson T.
Endothelial induced EMT in breast epithelial cells with stem cell properties.
PLoS ONE 6:e23833.1-e23833.11(2011)

PubMed=30684066; DOI=10.1007/s10911-018-09424-w
Briem E., Ingthorsson S., Traustadottir G.A., Hilmarsdottir B., Gudjonsson T.
Application of the D492 cell lines to explore breast morphogenesis, EMT and cancer progression in 3D culture.
J. Mammary Gland Biol. Neoplasia 24:139-147(2019)

Cross-references
Encyclopedic resources Wikidata; Q127380741
Gene expression databases GEO; GSM4224053
GEO; GSM4224054
GEO; GSM4224055
GEO; GSM4224056
Entry history
Entry creation30-Jan-2024
Last entry update10-Apr-2025
Version number3