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Cellosaurus D492 (CVCL_D1HJ)

[Text version]
Cell line name D492
Accession CVCL_D1HJ
Resource Identification Initiative To cite this cell line use: D492 (RRID:CVCL_D1HJ)
Comments Characteristics: Has a basal-like phenotype and has stem cell properties as demonstrated by its ability to differentiate into luminal- and myoepithelial cells (PubMed=21915264; PubMed=30684066).
Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Derived from site: In situ; Breast, epithelium; UBERON=UBERON_0008367.
Cell type: Luminal epithelial cell; CL=CL_0002326.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_D1HK (D492M)
Sex of cell Female
Age at sampling Adult
Category Transformed cell line
Publications

PubMed=11914275; DOI=10.1101/gad.952602; PMCID=PMC155359
Gudjonsson T., Villadsen R., Nielsen H.L., Ronnov-Jessen L., Bissell M.J., Petersen O.W.
Isolation, immortalization, and characterization of a human breast epithelial cell line with stem cell properties.
Genes Dev. 16:693-706(2002)

PubMed=17420292; DOI=10.1083/jcb.200611114; PMCID=PMC2064114
Villadsen R., Fridriksdottir A.J.R., Ronnov-Jessen L., Gudjonsson T., Rank F., LaBarge M.A., Bissell M.J., Petersen O.W.
Evidence for a stem cell hierarchy in the adult human breast.
J. Cell Biol. 177:87-101(2007)

PubMed=21915264; DOI=10.1371/journal.pone.0023833; PMCID=PMC3167828
Sigurdsson V., Hilmarsdottir B., Sigmundsdottir H., Fridriksdottir A.J.R., Ringner M., Villadsen R., Borg A., Agnarsson B.A., Petersen O.W., Magnusson M.K., Gudjonsson T.
Endothelial induced EMT in breast epithelial cells with stem cell properties.
PLoS ONE 6:e23833.1-e23833.11(2011)

PubMed=30684066; DOI=10.1007/s10911-018-09424-w
Briem E., Ingthorsson S., Traustadottir G.A., Hilmarsdottir B., Gudjonsson T.
Application of the D492 cell lines to explore breast morphogenesis, EMT and cancer progression in 3D culture.
J. Mammary Gland Biol. Neoplasia 24:139-147(2019)

Cross-references
Encyclopedic resources Wikidata; Q127380738
Entry history
Entry creation30-Jan-2024
Last entry update10-Sep-2024
Version number2