ID   D492M
AC   CVCL_D1HK
SY   D492 Mesenchymal
DR   GEO; GSM4224053
DR   GEO; GSM4224054
DR   GEO; GSM4224055
DR   GEO; GSM4224056
DR   Wikidata; Q127380741
RX   PubMed=21915264;
RX   PubMed=30684066;
CC   Characteristics: Has a mesenchymal phenotype, measured by a spindle like phenotype in culture and by marker expression. Has lost epithelial markers such as keratins, CDH1 and transcription factors such as TP63. Has gained mesenchymal marker expression including CDH2, VIM and alpha smooth muscle actin (PubMed=21915264; PubMed=30684066).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
CC   Omics: Transcriptomics; RNAseq.
CC   Derived from site: In situ; Breast, epithelium; UBERON=UBERON_0008367.
CC   Cell type: Luminal epithelial cell; CL=CL_0002326.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_D1HJ ! D492
SX   Female
AG   Adult
CA   Transformed cell line
DT   Created: 30-01-24; Last updated: 10-04-25; Version: 3
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RX   PubMed=21915264; DOI=10.1371/journal.pone.0023833; PMCID=PMC3167828;
RA   Sigurdsson V., Hilmarsdottir B., Sigmundsdottir H.,
RA   Fridriksdottir A.J.R., Ringner M., Villadsen R., Borg A.,
RA   Agnarsson B.A., Petersen O.W., Magnusson M.K., Gudjonsson T.;
RT   "Endothelial induced EMT in breast epithelial cells with stem cell
RT   properties.";
RL   PLoS ONE 6:e23833.1-e23833.11(2011).
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RX   PubMed=30684066; DOI=10.1007/s10911-018-09424-w;
RA   Briem E., Ingthorsson S., Traustadottir G.A., Hilmarsdottir B.,
RA   Gudjonsson T.;
RT   "Application of the D492 cell lines to explore breast morphogenesis,
RT   EMT and cancer progression in 3D culture.";
RL   J. Mammary Gland Biol. Neoplasia 24:139-147(2019).
//