ID   D492
AC   CVCL_D1HJ
DR   Wikidata; Q127380738
RX   PubMed=11914275;
RX   PubMed=17420292;
RX   PubMed=21915264;
RX   PubMed=30684066;
CC   Characteristics: Has a basal-like phenotype and has stem cell properties as demonstrated by its ability to differentiate into luminal- and myoepithelial cells (PubMed=21915264; PubMed=30684066).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
CC   Derived from site: In situ; Breast, epithelium; UBERON=UBERON_0008367.
CC   Cell type: Luminal epithelial cell; CL=CL_0002326.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   Adult
CA   Transformed cell line
DT   Created: 30-01-24; Last updated: 10-09-24; Version: 2
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RX   PubMed=11914275; DOI=10.1101/gad.952602; PMCID=PMC155359;
RA   Gudjonsson T., Villadsen R., Nielsen H.L., Ronnov-Jessen L.,
RA   Bissell M.J., Petersen O.W.;
RT   "Isolation, immortalization, and characterization of a human breast
RT   epithelial cell line with stem cell properties.";
RL   Genes Dev. 16:693-706(2002).
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RX   PubMed=17420292; DOI=10.1083/jcb.200611114; PMCID=PMC2064114;
RA   Villadsen R., Fridriksdottir A.J.R., Ronnov-Jessen L., Gudjonsson T.,
RA   Rank F., LaBarge M.A., Bissell M.J., Petersen O.W.;
RT   "Evidence for a stem cell hierarchy in the adult human breast.";
RL   J. Cell Biol. 177:87-101(2007).
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RX   PubMed=21915264; DOI=10.1371/journal.pone.0023833; PMCID=PMC3167828;
RA   Sigurdsson V., Hilmarsdottir B., Sigmundsdottir H.,
RA   Fridriksdottir A.J.R., Ringner M., Villadsen R., Borg A.,
RA   Agnarsson B.A., Petersen O.W., Magnusson M.K., Gudjonsson T.;
RT   "Endothelial induced EMT in breast epithelial cells with stem cell
RT   properties.";
RL   PLoS ONE 6:e23833.1-e23833.11(2011).
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RX   PubMed=30684066; DOI=10.1007/s10911-018-09424-w;
RA   Briem E., Ingthorsson S., Traustadottir G.A., Hilmarsdottir B.,
RA   Gudjonsson T.;
RT   "Application of the D492 cell lines to explore breast morphogenesis,
RT   EMT and cancer progression in 3D culture.";
RL   J. Mammary Gland Biol. Neoplasia 24:139-147(2019).
//